Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | RARB | P10826 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL36443 | 0.97 | GAA (0.56) | GAANR1I2CYP3A4SMN1; SMN2ALDH1A1 | |
| Lithium SCHEMBL30864217 | 0.95 | GAA (0.54) | GAANR1I2CYP3A4SMN1; SMN2ALDH1A1 | |
| SCHEMBL28651564 | 0.95 | GAA (0.54) | GAANR1I2CYP3A4SMN1; SMN2ALDH1A1 | |
| SCHEMBL15633667 | 0.94 | GAA (0.67) | GAANR1I2CYP3A4SMN1; SMN2ALDH1A1 | |
| Alcohol SCHEMBL28846453 | 0.94 | NR1I2 (0.56) | GAANR1I2CYP3A4SMN1; SMN2ALDH1A1 | |
| SCHEMBL28642707 | 0.94 | GAA (0.53) | GAANR1I2CYP3A4SMN1; SMN2ALDH1A1 | |
| Formic Acid SCHEMBL4884162 | 0.91 | GAA (0.50) | GAANR1I2CYP3A4SMN1; SMN2ALDH1A1 | |
| Phosphoric Acid SCHEMBL28885773 | 0.91 | GAA (0.50) | GAANR1I2CYP3A4SMN1; SMN2ALDH1A1 | |
| Oxirane SCHEMBL23673875 | 0.89 | GAA (0.49) | GAANR1I2CYP3A4SMN1; SMN2ALDH1A1 | |
| SCHEMBL15193850 | 0.89 | GAA (0.49) | GAANR1I2CYP3A4SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080258345-A1 | Liquid Radiation-Curing Compositions | STIFTUNG CAESAR (DE) | 2008-10-23 | — | — | US | disclosed |
| EP-1773901-A1 | LIQUID RADIATION-CURING COMPOSITIONS | Stiftung CAESAR (DE) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006005772-A1 | LIQUID RADIATION-CURING COMPOSITIONS | STIFTUNG CAESAR (DE) | 2006-01-19 | — | — | WO | disclosed |