SCHEMBL4884336

SCHEMBL4884336

NC(=O)c1cc(N)c[nH]1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30761593 0.82 CCNC (0.34)
SCHEMBL782011 0.81
SCHEMBL29868498 0.77 NOTUM (0.32)
SCHEMBL3641818 0.76 HTT (0.59)
SCHEMBL163391 0.76
SCHEMBL4852801 0.76
SCHEMBL163392 0.76
SCHEMBL1299791 0.74
SCHEMBL276048 0.74
SCHEMBL20792669 0.74

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070060523-A1 Process for the synthesis of distamycin and derivatives thereof using 1-methyl-4-formylamino-2-pyrrolecarbonyl chloride iteratively as an intermediate NAXOSPHARMA S.R.L. (IT) 2007-03-15 US claimed
EP-1641753-B1 PROCESS FOR THE SYNTHESIS OF DISTAMYCIN AND DERIVATIVES THEREOF USING 1-METHYL-4-FORMYLAMINO-2-PYRROLECARBONYL CHLORIDE ITERATIVELY AS AN INTERMEDIATE NAXOSPHARMA S R L (IT) 2006-10-18 EP claimed
EP-1641753-A1 PROCESS FOR THE SYNTHESIS OF DISTAMYCIN AND DERIVATIVES THEREOF USING 1-METHYL-4-FORMYLAMINO-2-PYRROLECARBONYL CHLORIDE ITERATIVELY AS AN INTERMEDIATE Naxospharma S.R.L. (IT) 2006-04-05 EP claimed
WO-2004106301-A1 PROCESS FOR THE SYNTHESIS OF DISTAMYCIN AND DERIVATIVES THEREOF USING 1-METHYL-4-FORMYLAMINO-2-PYRROLECARBONYL CHLORIDE ITERATIVELY AS AN INTERMEDIATE NAXOSPHARMA S.R.L. (IT) 2004-12-09 WO claimed
US-7449547-B2 Process for the synthesis of distamycin and derivatives thereof using 1-methyl-4-formylamino-2-pyrrolecarbonyl chloride iteratively as an intermediate NAXOPHARMA S.R.L. (IT) 2008-11-11 US disclosed
US-20070060523-A1 Process for the synthesis of distamycin and derivatives thereof using 1-methyl-4-formylamino-2-pyrrolecarbonyl chloride iteratively as an intermediate NAXOSPHARMA S.R.L. (IT) 2007-03-15 US disclosed
US-20070060523-A1 Process for the synthesis of distamycin and derivatives thereof using 1-methyl-4-formylamino-2-pyrrolecarbonyl chloride iteratively as an intermediate NAXOSPHARMA S.R.L. (IT) 2007-03-15 US disclosed
EP-1641753-B1 PROCESS FOR THE SYNTHESIS OF DISTAMYCIN AND DERIVATIVES THEREOF USING 1-METHYL-4-FORMYLAMINO-2-PYRROLECARBONYL CHLORIDE ITERATIVELY AS AN INTERMEDIATE NAXOSPHARMA S R L (IT) 2006-10-18 EP disclosed
EP-1641753-A1 PROCESS FOR THE SYNTHESIS OF DISTAMYCIN AND DERIVATIVES THEREOF USING 1-METHYL-4-FORMYLAMINO-2-PYRROLECARBONYL CHLORIDE ITERATIVELY AS AN INTERMEDIATE Naxospharma S.R.L. (IT) 2006-04-05 EP disclosed
WO-2004106301-A1 PROCESS FOR THE SYNTHESIS OF DISTAMYCIN AND DERIVATIVES THEREOF USING 1-METHYL-4-FORMYLAMINO-2-PYRROLECARBONYL CHLORIDE ITERATIVELY AS AN INTERMEDIATE NAXOSPHARMA S.R.L. (IT) 2004-12-09 WO disclosed
EP-0583161-B1 4-Aminopyrrole-2-carboxamide derivatives as antiviral agents PHARMACIA & UPJOHN SPA (IT) 1999-03-31 EP disclosed
US-5472976-A Poly 4-aminopyrrole-2-carboxyamide derivatives, and pharmaceutical compositions which contain them A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) 1995-12-05 US disclosed
US-5472976-A Poly 4-aminopyrrole-2-carboxyamide derivatives, and pharmaceutical compositions which contain them A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) 1995-12-05 US disclosed
EP-0574416-B1 POLY-4-AMINOPYRROLE-2-CARBOXYAMIDE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS WHICH CONTAIN THEM MENARINI FARMA IND (IT) 1995-09-06 EP disclosed
EP-0583161-A2 4-Aminopyrrole-2-carboxamide derivatives as antiviral agents PHARMACIA S.p.A. (IT) 1994-02-16 EP disclosed
EP-0574416-A1 POLY-4-AMINOPYRROLE-2-CARBOXYAMIDE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS WHICH CONTAIN THEM. MENARINI FARMA IND (IT) 1993-12-22 EP disclosed
WO-1992014707-A1 POLY-4-AMINOPYRROLE-2-CARBOXYAMIDE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS WHICH CONTAIN THEM A.MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) 1992-09-03 WO disclosed