⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11087996 | 0.70 | — | — | |
| SCHEMBL24497586 | 0.67 | — | — | |
| SCHEMBL3400994 | 0.67 | — | — | |
| SCHEMBL23913845 | 0.67 | — | — | |
| SCHEMBL164048 | 0.67 | — | — | |
| SCHEMBL13493151 | 0.65 | — | — | |
| SCHEMBL12303963 | 0.65 | — | — | |
| SCHEMBL12186085 | 0.65 | — | — | |
| SCHEMBL739059 | 0.65 | — | — | |
| SCHEMBL7764147 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7342016-B2 | Farnesyl protein transferase inhibitors as antitumor agents | SCHERING CORPORATION (US) | 2008-03-11 | — | — | US | disclosed |
| EP-1313725-B1 | TRICYCLIC ANTITUMOR COMPOUNDS BEING FARNESYL PROTEIN TRANSFERASE INHIBITORS | SCHERING CORP (US) | 2007-04-11 | — | — | EP | disclosed |
| US-20040122018-A1 | Novel farnesyl protein transferase inhibitors as antitumor agents | SCHERING CORPORATION | 2004-06-24 | — | — | US | disclosed |
| US-20040006087-A1 | Method of treating cancer using FPT inhibitors and antineoplastic agents | SCHERING CORPORATION | 2004-01-08 | — | — | US | disclosed |
| US-20030229099-A1 | Novel farnesyl protein transferase inhibitors as antitumor agents | PHARMACOPEIA DRUG DISCOVERY | 2003-12-11 | — | — | US | disclosed |
| US-20020198216-A1 | Novel farnesyl protein transferase inhibitors as antitumor agents | PHARMACOPEIA DRUG DISCOVERY | 2002-12-26 | — | — | US | disclosed |
| EP-0073562-B1 | HERBICIDAL TRIAZOLE UREAS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1988-11-09 | — | — | EP | disclosed |
| US-4578478-A | Thiazole derivatives and procedure of synthesis thereof | KOTOBUKI SEIYAKU COMPANY LIMITED (JP) | 1986-03-25 | — | — | US | disclosed |
| US-4421550-A | PRE- AND POSTEMERGENCE | E. I. DU PONT DE NEMOURS & CO. (US) | 1983-12-20 | — | — | US | disclosed |
| EP-0073562-A2 | Herbicidal triazole ureas | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1983-03-09 | — | — | EP | disclosed |
| US-4228291-A | INHIBITORS OF HISTAMINE ACTIVITY | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-10-14 | — | — | US | disclosed |
| US-4154844-A | ANTIHISTAMINE, GASTRIC JUICE ANTISECRETORY AGENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-05-15 | — | — | US | disclosed |
| US-4024271-A | INHIBITORS OF HISTAMINE ACTIVITY | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1977-05-17 | — | — | US | disclosed |
| US-4022797-A | PHARMACEUTICALS | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1977-05-10 | — | — | US | disclosed |