⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL42679 | 0.95 | — | — | |
| SCHEMBL1887087 | 0.95 | — | — | |
| SCHEMBL2357325 | 0.95 | TDP1 (1.00) | — | |
| Fluoride SCHEMBL8001538 | 0.91 | TDP1 (0.91) | — | |
| Methane SCHEMBL7603386 | 0.91 | — | — | |
| Hydrogen Peroxide SCHEMBL3473511 | 0.91 | — | — | |
| Fluoride SCHEMBL11776450 | 0.91 | — | — | |
| Fluoride SCHEMBL8001541 | 0.91 | — | — | |
| Water SCHEMBL21988146 | 0.91 | — | — | |
| Methyl Alcohol SCHEMBL3915651 | 0.91 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10059726-B2 | Base-catalyzed silylation of terminal olefinic C—H bonds | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2018-08-28 | — | — | US | claimed |
| EP-3303350-A1 | BASE-CATALYZED SILYLATION OF TERMINAL OLEFINIC C-H BONDS | California Institute of Technology (US) | 2018-04-11 | — | — | EP | claimed |
| WO-2016196250-A1 | BASE-CATALYZED SILYLATION OF TERMINAL OLEFINIC C-H BONDS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2016-12-08 | — | — | WO | claimed |
| US-20160347776-A1 | BASE-CATALYZED SILYLATION OF TERMINAL OLEFINIC C-H BONDS | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2016-12-01 | — | — | US | claimed |
| CN-104824786-A | Preservative for steamed twisted roll food | YANTAI SHUNLONG CHEMICAL ENGINEERING TECHNOLOGY CO LTD | 2015-08-12 | — | — | CN | claimed |
| EP-3909959-A1 | BASE-CATALYZED SILYLATION OF TERMINAL OLEFINIC C-H BONDS | California Institute of Technology (US) | 2021-11-17 | — | — | EP | disclosed |
| CN-113201005-A | Base-catalyzed silylation of terminal olefin C-H bonds | 加州理工学院 | 2021-08-03 | — | — | CN | disclosed |
| CN-107849066-B | Base-catalyzed silylation of terminal olefin C-H bonds | 加州理工学院 | 2021-05-28 | — | — | CN | disclosed |
| CN-106542996-B | A kind of synthetic method of 2- hydroxy-3-nitroacetophenone | 昆山力田医化科技有限公司 | 2019-08-30 | — | — | CN | disclosed |
| US-10059726-B2 | Base-catalyzed silylation of terminal olefinic C—H bonds | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2018-08-28 | — | — | US | disclosed |
| EP-3303350-A1 | BASE-CATALYZED SILYLATION OF TERMINAL OLEFINIC C-H BONDS | California Institute of Technology (US) | 2018-04-11 | — | — | EP | disclosed |
| WO-2016196250-A1 | BASE-CATALYZED SILYLATION OF TERMINAL OLEFINIC C-H BONDS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2016-12-08 | — | — | WO | disclosed |
| US-20030152520-A1 | 5-Substituted-2-arylpyridines | NEUROGEN CORPORATION | 2003-08-14 | — | — | US | disclosed |
| WO-2002096421-A1 | 5-SUBSTITUTED-2-ARYLPYRIDINES AS CRF1 MODULATORS | NEUROGEN CORPORATION (US) | 2002-12-05 | — | — | WO | disclosed |
| EP-0764166-B1 | CORTICOTROPIN RELEASING FACTOR ANTAGONISTS | PFIZER (US) | 2000-09-13 | — | — | EP | disclosed |
| US-5962479-A | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 1999-10-05 | — | — | US | disclosed |
| EP-0764166-A1 | CORTICOTROPIN RELEASING FACTOR ANTAGONISTS | PFIZER INC. (US) | 1997-03-26 | — | — | EP | disclosed |
| WO-1995033750-A1 | CORTICOTROPIN RELEASING FACTOR ANTAGONISTS | PFIZER INC. (US) | 1995-12-14 | — | — | WO | disclosed |
| CN-1013769-B | The method for preparing improved leukotriene antagonist | LILLY CO ELI (US) | 1991-09-04 | — | — | CN | disclosed |
| CN-1031223-A | Improvement about the leukotriene antagonist | LILLY CO ELI (US) | 1989-02-22 | — | — | CN | disclosed |