Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 8/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.39 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.34 |
| ▸ | PTPRC | P08575 | 1/20 | 0.34 |
| ▸ | PTPRF | P10586 | 1/20 | 0.34 |
| ▸ | CDC25B | P30305 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL233869 | 0.88 | TLR8 (0.40) | TLR8TLR7POLB | |
| SCHEMBL1095204 | 0.84 | TLR8 (0.49) | EGFRTLR8TLR7 | |
| SCHEMBL18297269 | 0.76 | TLR8 (0.49) | TLR8TLR7POLB | |
| SCHEMBL233010 | 0.76 | TLR8 (0.66) | TLR8TLR7 | |
| SCHEMBL18041439 | 0.74 | TLR8 (0.50) | TLR8TLR7TRPA1 | |
| Hydrochloric Acid SCHEMBL18041408 | 0.73 | TLR8 (0.49) | TLR8TLR7TRPA1 | |
| SCHEMBL1802552 | 0.73 | TLR8 (0.72) | TLR8TLR7 | |
| SCHEMBL233011 | 0.72 | EGFR (0.41) | EGFRTLR8TLR7ERN1PTPN1 | |
| SCHEMBL1095552 | 0.70 | TLR8 (0.49) | TLR8TLR7 | |
| SCHEMBL1238259 | 0.70 | TLR8 (0.59) | TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234251-A1 | 8-Substituted Benzoazepines as Toll-Like Receptor Modulators | ARRAY BIOPHARMA INC. (US) | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234251-A1 | 8-Substituted Benzoazepines as Toll-Like Receptor Modulators | TLR8, TLR7, TLR9 | EGFR 2187/4885TLR8 1/4885TLR7 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.