Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 2/20 | 0.36 |
| ▸ | SYK | P43405 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TNFRSF1A | P19438 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4886938 | 1.00 | MAPT (0.39) | MAPTABCB1MAOBARSYK | |
| SCHEMBL14306899 | 0.89 | AR (0.47) | MAPTABCB1MAOBARSMN1; SMN2 | |
| SCHEMBL14280886 | 0.86 | SYK (0.43) | MAPTABCB1MAOBARSYK | |
| SCHEMBL4852423 | 0.86 | SYK (0.43) | MAPTABCB1MAOBARSYK | |
| SCHEMBL4881621 | 0.85 | PTPN1 (0.44) | TNFRSF1ARELACYP3A4 | |
| SCHEMBL4881624 | 0.85 | PTPN1 (0.44) | TNFRSF1ARELACYP3A4 | |
| SCHEMBL4884102 | 0.79 | PDE4A (0.46) | MAPTSMN1; SMN2MAPK1TNFRSF1AMEN1 | |
| SCHEMBL4884108 | 0.79 | PDE4A (0.46) | MAPTSMN1; SMN2MAPK1TNFRSF1AMEN1 | |
| SCHEMBL14280893 | 0.79 | PDE4A (0.45) | MAPTSMN1; SMN2MAPK1TNFRSF1AMEN1 | |
| SCHEMBL4849810 | 0.77 | ABCB1 (0.43) | ABCB1MAOBARSYKSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080027075-A1 | Quaternary Amino-Function Chalcones | LICA PHARMACEUTICALS A/S (DK) | 2008-01-31 | — | — | US | claimed |
| EP-1682486-A1 | QUATERNARY AMINO-FUNCTIONAL CHALCONES | Lica Pharmaceuticals A/S (DK) | 2006-07-26 | — | — | EP | claimed |
| WO-2005042467-A1 | QUATERNARY AMINO-FUNCTIONAL CHALCONES | LICA PHARMACEUTICALS A/S (DK) | 2005-05-12 | — | — | WO | claimed |
| US-20080027075-A1 | Quaternary Amino-Function Chalcones | LICA PHARMACEUTICALS A/S (DK) | 2008-01-31 | — | — | US | disclosed |
| EP-1682486-A1 | QUATERNARY AMINO-FUNCTIONAL CHALCONES | Lica Pharmaceuticals A/S (DK) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005042467-A1 | QUATERNARY AMINO-FUNCTIONAL CHALCONES | LICA PHARMACEUTICALS A/S (DK) | 2005-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080027075-A1 | Quaternary Amino-Function Chalcones | NR2E1, BET1, NR0B1 | MAPT 4666/4885ABCB1 1518/4885MAOB 2291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.