Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 14/20 | 1.00 |
| ▸ | EGFR | P00533 | 8/20 | 0.81 |
| ▸ | GAK | O14976 | 1/20 | 0.81 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.81 |
| ▸ | LYN | P07948 | 1/20 | 0.81 |
| ▸ | RET | P07949 | 1/20 | 0.81 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.81 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.81 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.81 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.81 |
| ▸ | EPHA5 | P54756 | 1/20 | 0.81 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.81 |
| ▸ | EPHA4 | P54764 | 1/20 | 0.81 |
| ▸ | ADK | P55263 | 1/20 | 0.81 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.81 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4887398 | 0.92 | ERBB2 (0.86) | ERBB2EGFRGAKRIPK2LYN | |
| Hydrochloric Acid SCHEMBL4876811 | 0.92 | ERBB2 (0.85) | ERBB2EGFRGAKRIPK2LYN | |
| Sapitinib SCHEMBL29728247 | 0.90 | ERBB2 (1.00) | ERBB2EGFRGAKRIPK2LYN | |
| Sapitinib SCHEMBL202358 | 0.90 | ERBB2 (1.00) | ERBB2EGFRGAKRIPK2LYN | |
| Sapitinib SCHEMBL30362790 | 0.90 | ERBB2 (1.00) | ERBB2EGFRGAKRIPK2LYN | |
| SCHEMBL4887224 | 0.88 | ERBB2 (0.79) | ERBB2EGFRGAKRIPK2LYN | |
| SCHEMBL3390827 | 0.88 | ERBB2 (0.78) | ERBB2EGFRGAKRIPK2LYN | |
| SCHEMBL5207429 | 0.88 | EGFR (0.85) | ERBB2EGFRRIPK2RETEPHB2 | |
| SCHEMBL4885366 | 0.87 | ERBB2 (1.00) | ERBB2EGFRGAKRIPK2LYN | |
| SCHEMBL9883218 | 0.87 | EGFR (0.84) | ERBB2EGFRRIPK2RETEPHB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120329795-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB | 2012-12-27 | — | — | US | claimed |
| US-20080096881-A1 | Quinazoline Derivatives | ASTRAZENECA AB (SE) | 2008-04-24 | — | — | US | claimed |
| EP-1667992-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-01-24 | — | — | EP | claimed |
| EP-1667992-A1 | QUINAZOLINE DERIVATIVES | Astrazeneca AB (SE) | 2006-06-14 | — | — | EP | claimed |
| WO-2005028469-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-03-31 | — | — | WO | claimed |
| US-20120329795-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB | 2012-12-27 | — | — | US | disclosed |
| US-8318752-B2 | antiproliferative agent in the prevention or treatment of tumors which are sensitive to inhibition of EGF and erbB receptor tyrosine kinases | ASTRAZENECA AB (SE) | 2012-11-27 | — | — | US | disclosed |
| US-20080096881-A1 | Quinazoline Derivatives | ASTRAZENECA AB (SE) | 2008-04-24 | — | — | US | disclosed |
| EP-1667992-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-01-24 | — | — | EP | disclosed |
| EP-1667992-A1 | QUINAZOLINE DERIVATIVES | Astrazeneca AB (SE) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005028469-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120329795-A1 | QUINAZOLINE DERIVATIVES | EGFR, ERBB2, ERBB3 | ERBB2 2/4885EGFR 1/4885GAK 227/4885 |
| US-20080096881-A1 | Quinazoline Derivatives | EGFR, ERBB2, ERBB3 | ERBB2 2/4885EGFR 1/4885GAK 204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.