Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | CD38 | P28907 | 5/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL28177501 | 0.98 | DYRK1A (0.53) | DYRK1AKDRDYRK2DYRK1BPIM1 | |
| SCHEMBL24271909 | 0.90 | KDR (0.54) | DYRK1AKDRDYRK2DYRK1BPIM1 | |
| SCHEMBL11691085 | 0.88 | DYRK1A (0.46) | DYRK1AKDRDYRK2DYRK1BPIM1 | |
| SCHEMBL16159852 | 0.87 | PIM1 (0.47) | DYRK1AKDRDYRK2DYRK1BPIM1 | |
| SCHEMBL16159544 | 0.85 | KDR (0.50) | DYRK1AKDRDYRK2DYRK1BPIM1 | |
| SCHEMBL8686043 | 0.83 | — | — | |
| SCHEMBL16159847 | 0.83 | DYRK1A (0.45) | DYRK1AKDRDYRK2DYRK1BPIM1 | |
| SCHEMBL16159268 | 0.83 | DYRK1A (0.45) | DYRK1AKDRDYRK2DYRK1BPIM1 | |
| SCHEMBL16159722 | 0.82 | CD38 (0.48) | DYRK1AKDRDYRK2DYRK1BPIM1 | |
| SCHEMBL8770678 | 0.82 | DYRK1A (0.42) | DYRK1AKDRDYRK2DYRK1BPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 779 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024103023-A2 | 12-LIPOXYGENASE INHIBITORS FOR THE TREATMENT OF LUPUS | VERALOX THERAPEUTICS (US) | 2024-05-16 | — | — | WO | claimed |
| WO-2024019959-A1 | COMPOSITIONS FOR MODULATING LIPOXYGENASE AND METHODS OF USING SAME | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2024-01-25 | — | — | WO | claimed |
| EP-3054936-B1 | 4-((2-HYDROXY-3-METHOXYBENZYL)AMINO) BENZENESULFONAMIDE DERIVATIVES AS 12-LIPOXYGENASE INHIBITORS | EASTERN VIRGINIA MEDICAL SCHOOL (US) | 2023-10-18 | — | — | EP | claimed |
| CN-108017742-B | Preparation method of oligomeric isobutene for synthesizing squalane | 万华化学集团股份有限公司 | 2020-05-08 | — | — | CN | claimed |
| CN-108017742-A | A kind of preparation method for the oligomerising isobutene for being used to synthesize saualane | 万华化学集团股份有限公司 | 2018-05-11 | — | — | CN | claimed |
| US-20170095483-A1 | DGAT1 INHIBITION FOR TREATMENT OF DEMYELINATING INFLAMMATORY DISEASE | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2017-04-06 | — | — | US | claimed |
| CN-103965136-B | A kind of method preparing N-methylthiazoline-2-ketone compounds | 苏州波菲特新材料科技有限公司 | 2016-09-07 | — | — | CN | claimed |
| WO-2015187704-A1 | DGAT1 INHIBITION FOR TREATMENT OF DEMYELINATING INFLAMMATORY DISEASE | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2015-12-10 | — | — | WO | claimed |
| CN-103965136-A | Method for preparing N-Methylthiazoline-2-ketone compound | SUZHOU BOFEITE NEW MATERIALS TECHNOLOGY CO LTD | 2014-08-06 | — | — | CN | claimed |
| US-8163900-B2 | Seven-membered heterocyclic carbenes and their metal complexes | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2012-04-24 | — | — | US | claimed |
| US-5142545-A | LASER DYE | LAMBDA PHYSIK GESELLSCHAFT ZUR HERSTELLUNG VON LASERN MBH (DE) | 1992-08-25 | — | — | US | claimed |
| US-4891305-A | LASERS | RICOH CO., LTD. (JP) | 1990-01-02 | — | — | US | claimed |
| US-4418070-A | 5-PHENYL-THIAZOLES | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1983-11-29 | — | — | US | claimed |
| US-4102688-A | CONTAINING PYRAZOLO(3,4-B)PYRIDINE/3,6-DIONE MOIETY | FUJI PHOTO FILM CO., LTD. (JP) | 1978-07-25 | — | — | US | claimed |
| US-3970461-A | Fogged, direct-positive silver halide emulsion containing carbocyanine dye having indolenine nucleus | FUJI PHOTO FILM CO., LTD. (JA) | 1976-07-20 | — | — | US | claimed |
| JP-57134417-A | — | — | None | — | — | JP | disclosed |
| US-12544362-B2 | Methods of treating acute respiratory distress syndrome with activators of Tie-2 | EyePoint Pharmaceuticals, Inc. (US) | 2026-02-10 | — | — | US | disclosed |
| US-3936308-A | Photographic emulsions containing methine dyes having a 1H-imidazo[4,5-b]pyrazine nucleus | EASTMAN KODAK COMPANY (US) | 1976-02-03 | — | — | US | disclosed |
| US-3935010-A | IMIDAZOQUINOXALINE DESENSITIZER | EASTMAN KODAK COMPANY (US) | 1976-01-27 | — | — | US | disclosed |
| US-3933507-A | LIGHT INSENSITIVE SILVER SALT, POLYMETHINE SENSITIZER | AGFA-GEVAERT, A.G. (DT) | 1976-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12544362-B2 | Methods of treating acute respiratory distress syndrome with activators of Tie-2 | TIE1, ACE2, TEK | DYRK1A 746/4885KDR 12/4885DYRK2 530/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.