⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6708557 | 0.77 | — | — | |
| SCHEMBL21633854 | 0.69 | — | — | |
| SCHEMBL28482874 | 0.68 | HDAC1 (0.33) | — | |
| SCHEMBL28456196 | 0.66 | — | — | |
| SCHEMBL11600441 | 0.66 | — | — | |
| SCHEMBL28025890 | 0.65 | — | — | |
| SCHEMBL28354522 | 0.60 | — | — | |
| SCHEMBL4308456 | 0.59 | — | — | |
| SCHEMBL27705308 | 0.59 | — | — | |
| SCHEMBL28564544 | 0.58 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101460178-B | Immune regulative RNA (SIMRA) compound for the stabilisation of TLR7 and TLR8 | 艾德拉药物股份有限公司 | 2016-12-07 | — | — | CN | claimed |
| US-9243050-B2 | Stabilized immune modulatory RNA (SIMRA) compounds for TLR7 and TLR8 | Idera Pharamaceuticals, Inc. (US) | 2016-01-26 | — | — | US | claimed |
| EP-2021008-B1 | STABILIZED IMMUNE MODULATORY RNA (SIMRA) COMPOUNDS FOR TLR7 AND TLR8 | IDERA PHARMACEUTICALS INC (US) | 2015-12-02 | — | — | EP | claimed |
| US-20140308300-A1 | STABILIZED IMMUNE MODULATORY RNA (SIMRA) COMPOUNDS FOR TLR7 AND TLR8 | NOVAQUEST CO-INVESTMENT FUND XV, L.P. | 2014-10-16 | — | — | US | claimed |
| US-8853375-B2 | Toll like receptor modulators | IDERA PHARMACEUTICALS, INC. (US) | 2014-10-07 | — | — | US | claimed |
| US-8759310-B2 | Stabilized immune modulatory RNA (SIMRA) compounds for TLR7 and TLR8 | IDERA PHARMACEUTICALS, INC. (US) | 2014-06-24 | — | — | US | claimed |
| US-20130202584-A1 | STABILIZED IMMUNE MODULATORY RNA (SIMRA) COMPOUNDS FOR TLR7 AND TLR8 | IDERA PHARMACEUTICALS, INC. | 2013-08-08 | — | — | US | claimed |
| EP-2179061-B1 | TOLL LIKE RECEPTOR MODULATORS | IDERA PHARMACEUTICALS INC (US) | 2012-10-03 | — | — | EP | claimed |
| US-8106173-B2 | Stabilized immune modulatory RNA (SIMRA) compounds for TLR7 and TLR8 | IDERA PHARMACEUTICALS, INC. (US) | 2012-01-31 | — | — | US | claimed |
| EP-2179061-A2 | TOLL LIKE RECEPTOR MODULATORS | Idera Pharmaceuticals, Inc. (US) | 2010-04-28 | — | — | EP | claimed |
| JP-2009533348-A | — | — | 2009-09-17 | — | — | JP | claimed |
| US-20090053148-A1 | TOLL LIKE RECEPTOR MODULATORS | IDERA PHARMACEUTICALS, INC. | 2009-02-26 | — | — | US | claimed |
| WO-2009023819-A2 | TOLL LIKE RECEPTOR MODULATORS | IDERA PHARMACEUTICALS, INC. (US) | 2009-02-19 | — | — | WO | claimed |
| EP-2021008-A2 | STABILIZED IMMUNE MODULATORY RNA (SIMRA) COMPOUNDS FOR TLR7 AND TLR8 | Idera Pharmaceuticals, Inc. (US) | 2009-02-11 | — | — | EP | claimed |
| US-20080171712-A1 | At least two oligonucleotides having modified purine bases, such as deazaguanosines or deaza-adenosines, linked by an alkyl or phenolic diol or triol; vaccines, DNA vaccines; anticarcinogenic, antiallergenic, antiinflammatory agents; bronchodilators | IDERA PHARMACEUTICALS, INC. | 2008-07-17 | — | — | US | claimed |
| WO-2007117686-A2 | STABILIZED IMMUNE MODULATORY RNA (SIMRA) COMPOUNDS FOR TLR7 AND TLR8 | IDERA PHARMACEUTICALS, INC. (US) | 2007-10-18 | — | — | WO | claimed |
| EP-2021008-B1 | STABILIZED IMMUNE MODULATORY RNA (SIMRA) COMPOUNDS FOR TLR7 AND TLR8 | IDERA PHARMACEUTICALS INC (US) | 2015-12-02 | — | — | EP | disclosed |