Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 13/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2995690 | 0.81 | PPARG (0.49) | PPARGPPARDPPARAIGF1RAR | |
| SCHEMBL17558513 | 0.80 | HDAC1 (0.47) | HDAC1HDAC6PPARGPPARDPPARA | |
| SCHEMBL6171177 | 0.80 | IGF1R (0.61) | HDAC1HDAC6IGF1R | |
| SCHEMBL19410384 | 0.75 | HDAC1 (0.42) | HDAC1HDAC6IGF1R | |
| SCHEMBL13039126 | 0.73 | IGF1R (0.72) | PPARGPPARDPPARAIGF1R | |
| SCHEMBL19410412 | 0.72 | HDAC1 (0.39) | HDAC1HDAC6PPARGPPARDPPARA | |
| SCHEMBL6173255 | 0.72 | HDAC6 (0.46) | HDAC1HDAC6PPARGPPARDPPARA | |
| SCHEMBL17571861 | 0.71 | IGF1R (0.47) | PPARGPPARDPPARAIGF1R | |
| SCHEMBL2941665 | 0.71 | IGF1R (0.59) | PPARGPPARDPPARAIGF1R | |
| SCHEMBL2936825 | 0.71 | IGF1R (0.52) | HDAC1HDAC6PPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7354933-B2 | Protein kinase inhibitors; antitumor agents; such as 5-methyl-1-quinol-4-ylmethyl-3-(4-trifluoromethanesulfonylphenyl)imidazolidine-2,4-dione trifluoroacetate | AVENTIS PHARMA SA (FR) | 2008-04-08 | — | — | US | disclosed |