Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 19/20 | 0.60 |
| ▸ | AURKA | O14965 | 4/20 | 0.45 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.45 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | RET | P07949 | 2/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.45 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | LTK | P29376 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.45 |
| ▸ | CLK2 | P49760 | 1/20 | 0.45 |
| ▸ | CDK7 | P50613 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4065652 | 0.86 | NTRK1 (0.56) | NTRK1JAK2JAK3 | |
| SCHEMBL4618549 | 0.86 | NTRK1 (0.67) | NTRK1AURKAJAK2RETFGFR1 | |
| SCHEMBL23808896 | 0.83 | NTRK1 (0.75) | NTRK1AURKANTRK3NTRK2JAK2 | |
| SCHEMBL4068254 | 0.82 | NTRK1 (0.64) | NTRK1AURKA | |
| SCHEMBL4891282 | 0.81 | NTRK1 (0.88) | NTRK1IGF1R | |
| SCHEMBL3340493 | 0.80 | NTRK1 (0.80) | NTRK1AURKANTRK3NTRK2JAK2 | |
| SCHEMBL23217067 | 0.80 | NTRK1 (0.80) | NTRK1AURKANTRK3NTRK2JAK2 | |
| SCHEMBL29794572 | 0.80 | NTRK1 (0.80) | NTRK1AURKANTRK3NTRK2JAK2 | |
| SCHEMBL4696871 | 0.78 | NTRK1 (0.43) | NTRK1AURKAJAK2JAK3CDK9 | |
| SCHEMBL4071538 | 0.78 | NTRK1 (0.73) | NTRK1AURKAJAK2RETFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194606-A1 | Pyrazolyl-Amino-Substituted Pyrimidines and Their Use in the Treatment of Cancer | ASTRAZENECA (SE) | 2008-08-14 | — | — | US | claimed |
| US-20140179664-A1 | Heterocyclyl Pyrimidine Analogues As JAK Inhibitors | CELLZOME LIMITED (GB) | 2014-06-26 | — | — | US | disclosed |
| US-20140179664-A1 | Heterocyclyl Pyrimidine Analogues As JAK Inhibitors | CELLZOME LIMITED (GB) | 2014-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140179664-A1 | Heterocyclyl Pyrimidine Analogues As JAK Inhibitors | JAK1, JAK3, JAK2 | NTRK1 4690/4885AURKA 1305/4885NTRK3 4001/4885 |
| US-20080194606-A1 | Pyrazolyl-Amino-Substituted Pyrimidines and Their Use in the Treatment of Cancer | TYMS, TYMP, DPYD | NTRK1 4196/4885AURKA 35/4885NTRK3 2519/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.