Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 16/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 16/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 15/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 14/20 | 0.46 |
| ▸ | TSHR | P16473 | 11/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 7/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.46 |
| ▸ | USP2 | O75604 | 3/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 3/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4721501 | 0.87 | BRAF (0.49) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR | |
| SCHEMBL4892592 | 0.83 | EGFR (0.41) | EGFRERBB2 | |
| SCHEMBL4720811 | 0.82 | EGFR (0.40) | EGFRERBB2KDM4E | |
| SCHEMBL4896850 | 0.82 | EGFR (0.41) | EGFRERBB2 | |
| SCHEMBL4720750 | 0.80 | EGFR (0.38) | EGFRERBB2 | |
| SCHEMBL4897449 | 0.80 | EGFR (0.41) | MEN1KMT2AEGFRERBB2 | |
| SCHEMBL4912909 | 0.79 | EGFR (0.39) | CYP1A2CYP3A4CYP2C19CYP2D6LMNA | |
| SCHEMBL4718146 | 0.69 | MEN1 (0.48) | MEN1KMT2A | |
| SCHEMBL4714761 | 0.69 | FGFR1 (0.38) | EGFR | |
| SCHEMBL4719574 | 0.69 | MEN1 (0.48) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080027076-A1 | Pyrimidines With Tie2 (Tek) Activity | ASTRAZENECA AB (SE) | 2008-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080027076-A1 | Pyrimidines With Tie2 (Tek) Activity | TIE1, TEK, TEKT1 | CYP1A2 2420/4885CYP3A4 4242/4885CYP2C19 3624/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.