Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 3/20 | 0.62 |
| ▸ | KIT | P10721 | 2/20 | 0.62 |
| ▸ | LCK | P06239 | 5/20 | 0.61 |
| ▸ | BRAF | P15056 | 11/20 | 0.59 |
| ▸ | KDR | P35968 | 3/20 | 0.56 |
| ▸ | SRC | P12931 | 2/20 | 0.56 |
| ▸ | INSR | P06213 | 1/20 | 0.56 |
| ▸ | LYN | P07948 | 1/20 | 0.56 |
| ▸ | HCK | P08631 | 1/20 | 0.56 |
| ▸ | RAF1 | P04049 | 1/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.53 |
| ▸ | BTK | Q06187 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.51 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL374503 | 0.90 | LCK (0.67) | CSF1RKITLCKBRAFKDR | |
| SCHEMBL374688 | 0.89 | BRAF (0.60) | CSF1RKITLCKBRAFKDR | |
| SCHEMBL13855390 | 0.89 | CSF1R (0.55) | CSF1RKITLCKBRAFKDR | |
| SCHEMBL374813 | 0.88 | CSF1R (0.57) | CSF1RKITLCKBRAFKDR | |
| SCHEMBL374549 | 0.88 | LCK (0.54) | CSF1RKITLCKBRAFKDR | |
| SCHEMBL374709 | 0.88 | BRAF (0.58) | CSF1RKITLCKBRAFKDR | |
| SCHEMBL374318 | 0.88 | CSF1R (0.54) | CSF1RKITLCKBRAFKDR | |
| SCHEMBL374311 | 0.86 | CSF1R (0.53) | CSF1RKITLCKBRAFKDR | |
| SCHEMBL374414 | 0.86 | CSF1R (0.53) | CSF1RKITLCKBRAFKDR | |
| SCHEMBL374105 | 0.86 | LCK (0.55) | CSF1RKITLCKBRAFKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2008503537-A | — | — | 2008-02-07 | — | — | JP | claimed |
| EP-1761505-A1 | PYRIMIDINE UREA DERIVATIVES AS KINASE INHIBITORS | Novartis AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2006000420-A1 | PYRIMIDINE UREA DERIVATIVES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2006-01-05 | — | — | WO | claimed |