⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7072753 | 0.81 | — | — | |
| SCHEMBL11376825 | 0.80 | TRIM24 (0.31) | — | |
| SCHEMBL11376830 | 0.80 | TRIM24 (0.31) | — | |
| SCHEMBL52489 | 0.80 | — | — | |
| Iodide SCHEMBL11339547 | 0.77 | — | — | |
| Methane SCHEMBL29266080 | 0.77 | — | — | |
| Cyclopropane SCHEMBL27761058 | 0.74 | — | — | |
| SCHEMBL6479326 | 0.71 | CYP1A2 (0.52) | — | |
| Methylamine SCHEMBL8994444 | 0.71 | — | — | |
| SCHEMBL388722 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4126871-B1 | TRIAZOLONE COMPOUNDS | HEPTARES THERAPEUTICS LTD (GB) | 2024-05-08 | — | — | EP | disclosed |
| US-20230271964-A1 | 5-AMINO-8-(4-PYRIDYL)-[1,2,4]TRIAZOLO[4,3-C]PYRIMIDIN-3-ONE COMPOUNDS FOR USE AGAINST CANCER | NXERA PHARMA UK LIMITED (GB) | 2023-08-31 | — | — | US | disclosed |
| US-20230146796-A1 | TRIAZOLONE COMPOUNDS | ASTRAZENECA AB (SE) | 2023-05-11 | — | — | US | disclosed |
| US-20230146483-A1 | 5-AMINO-8-(4-PYRIDYL)-[1,2,4]TRIAZOLO[4,3-C]PYRIMIDIN-3-ONE COMPOUNDS FOR USE AGAINST CANCER | NXERA PHARMA UK LIMITED (GB) | 2023-05-11 | — | — | US | disclosed |
| CN-115867550-A | Triazolone compounds | 赫普泰雅治疗有限公司 | 2023-03-28 | — | — | CN | disclosed |
| CN-115867280-A | 5-amino-8- (4-pyridinyl) - [1,2,4] triazolo [4,3-C ] pyrimidin-3-one compounds for use in cancer therapy | 赫普泰雅治疗有限公司 | 2023-03-28 | — | — | CN | disclosed |
| CN-115867282-A | 5-amino-8- (4-pyridyl) - [1,2,4] triazolo [4,3-C ] pyrimidin-3-one compounds for anticancer | 赫普泰雅治疗有限公司 | 2023-03-28 | — | — | CN | disclosed |
| EP-4126872-A1 | 5-AMINO-8-(4-PYRIDYL)-[1,2,4]TRIAZOLO[4,3-C]PYRIMIDIN-3-ONE COMPOUNDS FOR USE AGAINST CANCER | Heptares Therapeutics Limited (GB) | 2023-02-08 | — | — | EP | disclosed |
| EP-4126873-A1 | 5-AMINO-8-(4-PYRIDYL)-[1,2,4]TRIAZOLO[4,3-C]PYRIMIDIN-3-ONE COMPOUNDS FOR USE AGAINST CANCER | Heptares Therapeutics Limited (GB) | 2023-02-08 | — | — | EP | disclosed |
| EP-4126871-A1 | TRIAZOLONE COMPOUNDS | Heptares Therapeutics Limited (GB) | 2023-02-08 | — | — | EP | disclosed |
| EP-1713783-A2 | SULPHONAMIDE SUBSTITUTED TRIAZINES AS CHEMOKINE RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2006-10-25 | — | — | EP | disclosed |
| WO-2006064228-A2 | THIAZOLOPYRAMIDINE COMPOUNDS FOR THE MODULATION OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2006-06-22 | — | — | WO | disclosed |
| WO-2006024823-A1 | PYRIMIDINE SULPHONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2006-03-09 | — | — | WO | disclosed |
| US-20060025432-A1 | Pyrimidyl sulphone amide derivatives as chemokine receptor modulators | ASTRAZENECA AB (SE) | 2006-02-02 | — | — | US | disclosed |
| US-20060004030-A1 | Pyrimidine derivatives as modulators of chemokine receptor activity | ASTRAZENECA AB (SE) | 2006-01-05 | — | — | US | disclosed |
| WO-2005070903-A2 | SULPHONAMIDE SUBSTITUTED TRIAZINES AS CHEMOKINE RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2005-08-04 | — | — | WO | disclosed |
| EP-1539713-A1 | PYRIMIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Astrazeneca AB (SE) | 2005-06-15 | — | — | EP | disclosed |
| EP-1527051-A1 | PYRIMIDYL SULPHONE AMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | Astrazeneca AB (SE) | 2005-05-04 | — | — | EP | disclosed |
| WO-2004018435-A1 | PYRIMIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2004-03-04 | — | — | WO | disclosed |
| WO-2004011443-A1 | PYRIMIDYL SULPHONE AMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |