Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 14/20 | 0.69 |
| ▸ | HSP90AB1 | P08238 | 11/20 | 0.69 |
| ▸ | TRAP1 | Q12931 | 4/20 | 0.66 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.66 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.66 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.63 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.63 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.63 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.63 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.63 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.63 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.63 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.63 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.63 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14067098 | 0.90 | HDAC3 (0.58) | HSP90AA1HSP90AB1TRAP1ERBB2HSP90B1 | |
| SCHEMBL4892928 | 0.90 | HDAC3 (0.71) | HSP90AA1HSP90AB1ERBB2HDAC3HDAC4 | |
| SCHEMBL4903396 | 0.87 | HSP90AB1 (0.68) | HSP90AA1HSP90AB1TRAP1ERBB2HSP90B1 | |
| SCHEMBL15609765 | 0.86 | HSP90AA1 (0.76) | HSP90AA1HSP90AB1TRAP1ERBB2HSP90B1 | |
| SCHEMBL29581799 | 0.86 | HSP90AA1 (0.76) | HSP90AA1HSP90AB1TRAP1ERBB2HSP90B1 | |
| SCHEMBL15610030 | 0.86 | HSP90AA1 (0.73) | HSP90AA1HSP90AB1TRAP1ERBB2HSP90B1 | |
| SCHEMBL1745324 | 0.85 | HSP90AA1 (0.76) | HSP90AA1HSP90AB1HSP90B1 | |
| SCHEMBL4788395 | 0.85 | HSP90AB1 (0.76) | HSP90AA1HSP90AB1TRAP1ERBB2HSP90B1 | |
| SCHEMBL18388884 | 0.85 | HSP90AB1 (0.76) | HSP90AA1HSP90AB1TRAP1ERBB2HSP90B1 | |
| SCHEMBL3465181 | 0.85 | HSP90AB1 (0.76) | HSP90AA1HSP90AB1TRAP1ERBB2HSP90B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234297-A1 | HSP90 Inhibitors Containing a Zinc Binding Moiety | CURIS, INC. | 2008-09-25 | — | — | US | disclosed |
| US-20080221132-A1 | Multi-Functional Small Molecules as Anti-Proliferative Agents | CURIS, INC. | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221132-A1 | Multi-Functional Small Molecules as Anti-Proliferative Agents | HDAC1, HDAC6, HDAC5 | HSP90AA1 417/4885HSP90AB1 157/4885TRAP1 379/4885 |
| US-20080234297-A1 | HSP90 Inhibitors Containing a Zinc Binding Moiety | HSP90AB1, HSP90AB2P, HSP90B1 | HSP90AA1 4/4885HSP90AB1 1/4885TRAP1 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.