⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11130944 | 0.79 | CES1 (0.41) | — | |
| SCHEMBL7644150 | 0.77 | TSHR (0.46) | — | |
| SCHEMBL23706122 | 0.77 | TDP1 (0.42) | — | |
| SCHEMBL23706124 | 0.77 | TDP1 (0.42) | — | |
| SCHEMBL8924966 | 0.77 | TSHR (0.46) | — | |
| SCHEMBL2234110 | 0.73 | CES1 (0.47) | — | |
| SCHEMBL188438 | 0.73 | — | — | |
| SCHEMBL525632 | 0.73 | — | — | |
| SCHEMBL1306184 | 0.73 | — | — | |
| SCHEMBL1193713 | 0.73 | CES1 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 149 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108531161-B | Quantum dot and quantum dot dispersion system | 苏州星烁纳米科技有限公司 | 2022-02-22 | — | — | CN | claimed |
| US-11242345-B2 | Sulfonimidoylpurinone compounds and methods of treatment using the same | HOFFMANN-LA ROCHE INC. (US) | 2022-02-08 | — | — | US | claimed |
| EP-3317289-B1 | NOVEL SUBSTITUTED AMINOTHIAZOLOPYRIMIDINEDIONE FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION | HOFFMANN LA ROCHE (CH) | 2021-10-27 | — | — | EP | claimed |
| US-10975098-B2 | Substituted aminothiazolopyrimidinediones for the treatment of virus infection | HOFFMANN-LA ROCHE INC. (US) | 2021-04-13 | — | — | US | claimed |
| US-20200231600-A1 | SUBSTITUTED AMINOTHIAZOLOPYRIMIDINEDIONES FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION | HOFFMANN-LA ROCHE INC. (US) | 2020-07-23 | — | — | US | claimed |
| CN-107580596-B | Sulfimidoylpurine ketone compounds and derivatives for the treatment and prevention of viral infections | 豪夫迈·罗氏有限公司 | 2020-07-14 | — | — | CN | claimed |
| CN-107820498-B | Substituted aminothiazolopyrimidinediones for the treatment and prevention of viral infections | 豪夫迈·罗氏有限公司 | 2020-06-19 | — | — | CN | claimed |
| US-20200109144-A1 | Sulfonimidoylpurinone Compounds | HOFFMANN-LA ROCHE INC. (US) | 2020-04-09 | — | — | US | claimed |
| US-10590146-B2 | Substituted aminothiazolopyrimidinediones | HOFFMANN-LA ROCHE INC. (US) | 2020-03-17 | — | — | US | claimed |
| EP-3294740-B1 | NOVEL SULFONIMIDOYLPURINONE COMPOUNDS AND DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION | HOFFMANN LA ROCHE (CH) | 2019-09-04 | — | — | EP | claimed |
| US-20090176799-A1 | PHOSPHODIESTERASE 4 INHIBITORS | RUIPING LIU | 2009-07-09 | — | — | US | claimed |
| US-20080146547-A1 | PHTHALAZINE DERIVATIVES | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2008-06-19 | — | — | US | claimed |
| WO-2008061108-A2 | PHTHALAZINE DERIVATIVES | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2008-05-22 | — | — | WO | claimed |
| US-20050272803-A1 | Phosphodiesterase 4 inhibitors | RUIPING LIU | 2005-12-08 | — | — | US | claimed |
| EP-1435944-A1 | 4(4-ALKOXY-3-HYDROXYPHENYL)-2-PYRROLIDONE DERIVATIVES AS PDE-4 INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL SYNDROMES | Memory Pharmaceutical Corporation (US) | 2004-07-14 | — | — | EP | claimed |
| US-20030139406-A1 | Phosphodiesterase 4 inhibitors | MEMORY PHARMACEUTICALS CORP. | 2003-07-24 | — | — | US | claimed |
| WO-2003032981-A1 | 4-(4-ALKOXY-3-HYDROXYPHENYL)-2-PYRROLIDONE DERIVATIVES AS PDE-4 INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL SYNDROMES | MEMORY PHARMACEUTICALS CORPORATION (US) | 2003-04-24 | — | — | WO | claimed |
| US-4512989-A | IMIDOESTERS OR IMIDOTHIOESTERS | HOKKO CHEMICAL INDUSTRY CO., LTD. (JP) | 1985-04-23 | — | — | US | claimed |
| US-4243405-A | HYDROXYALKYLTRIAZOLES AND DERIVATIVES, PLANT GROWTH REGULATORS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1981-01-06 | — | — | US | claimed |
| EP-0001682-A2 | Heterocyclic compounds and their use as pesticides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1979-05-02 | — | — | EP | claimed |