Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 8/20 | 1.00 |
| ▸ | AKR1A1 | P14550 | 1/20 | 1.00 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.48 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.41 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Zenarestat SCHEMBL29688249 | 1.00 | AKR1B1 (1.00) | AKR1B1AKR1A1HDAC6AKR1B10MEN1 | |
| Zenarestat SCHEMBL30583313 | 1.00 | AKR1B1 (1.00) | AKR1B1AKR1A1HDAC6AKR1B10MEN1 | |
| SCHEMBL10487878 | 0.92 | AKR1B1 (0.86) | AKR1B1AKR1A1HDAC6AKR1B10MEN1 | |
| SCHEMBL10488007 | 0.92 | AKR1B1 (0.85) | AKR1B1AKR1A1HDAC6AKR1B10MEN1 | |
| Zenarestat SCHEMBL10487895 | 0.90 | AKR1B1 (0.81) | AKR1B1AKR1A1HDAC6AKR1B10MEN1 | |
| SCHEMBL9319101 | 0.89 | AKR1B1 (0.81) | AKR1B1AKR1A1HDAC6AKR1B10MEN1 | |
| SCHEMBL10487834 | 0.88 | AKR1B1 (0.79) | AKR1B1AKR1A1AKR1B10MEN1CYP1A2 | |
| SCHEMBL10487869 | 0.88 | AKR1B1 (0.78) | AKR1B1AKR1A1HDAC6AKR1B10MEN1 | |
| SCHEMBL10487836 | 0.88 | AKR1B1 (0.78) | AKR1B1AKR1A1HDAC6AKR1B10MEN1 | |
| SCHEMBL9056716 | 0.88 | AKR1B1 (0.78) | AKR1B1AKR1A1HDAC6AKR1B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2944 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240374693-A1 | TREATMENT AND DETECTION OF INHERITED NEUROPATHIES AND ASSOCIATED DISORDERS | UNIVERSITY OF ROCHESTER | 2024-11-14 | — | — | US | claimed |
| US-12083168-B2 | Treatment and detection of inherited neuropathies and associated disorders | UNIVERSITY OF MIAMI (US) | 2024-09-10 | — | — | US | claimed |
| WO-2024053761-A1 | COMPOSITION FOR PROMOTING MYOBLAST PROLIFERATION AND DIFFERENTIATION CONTAINING ALDOSE REDUCTASE INHIBITOR | 애니머스큐어 주식회사 | 2024-03-14 | — | — | WO | claimed |
| US-20240003908-A1 | POLYOL BIOMARKERS FOR CONGENITAL DISORDERS OF GLYCOSYLATION | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2024-01-04 | — | — | US | claimed |
| US-20230293642-A9 | TREATMENT AND DETECTION OF INHERITED NEUROPATHIES AND ASSOCIATED DISORDERS | UNIVERSITY OF ROCHESTER | 2023-09-21 | — | — | US | claimed |
| EP-4244243-A1 | POLYOL BIOMARKERS FOR CONGENITAL DISORDERS OF GLYCOSYLATION | Mayo Foundation for Medical Education and Research (US) | 2023-09-20 | — | — | EP | claimed |
| US-20220249624-A1 | TREATMENT AND DETECTION OF INHERITED NEUROPATHIES AND ASSOCIATED DISORDERS | UNIV MIAMI (US) | 2022-08-11 | — | — | US | claimed |
| WO-2022103815-A1 | POLYOL BIOMARKERS FOR CONGENITAL DISORDERS OF GLYCOSYLATION | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2022-05-19 | — | — | WO | claimed |
| US-20220125890-A1 | TREATMENT AND DETECTION OF INHERITED NEUROPATHIES AND ASSOCIATED DISORDERS | UNIVERSITY OF ROCHESTER | 2022-04-28 | — | — | US | claimed |
| US-20220125766-A1 | METHODS FOR TREATING CONGENITAL DISORDERS OF GLYCOSYLATION | MAGGIES PEARL LLC (US) | 2022-04-28 | — | — | US | claimed |
| EP-1097707-A1 | Treatment of female sexual dysfunction | Pfizer Limited (GB) | 2001-05-09 | — | — | EP | claimed |
| US-6218409-B1 | ADMINISTERING INSULIN SENSITIVITY ENHANCER IN COMBINATION WITH AN ALDOSE REDUCTASE INHIBITOR FOR REDUCING SIDE EFFECTS OF DIABETIC DRUGS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-04-17 | — | — | US | claimed |
| US-6156773-A | Pharmaceutical composition | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-12-05 | — | — | US | claimed |
| WO-2000045818-A1 | USE OF 3-HYDROXY-3-METHYLGLUTARYL COENZYM A REDUCTASE INHIBITORS FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF DIABETIC NEUROPATHY | ASTRAZENECA AB (SE) | 2000-08-10 | — | — | WO | claimed |
| CN-1261804-A | Pharmaceutical compositions comprising an aldose reductase inhibitor and an ACE inhibitor | ZENECA LTD (GB) | 2000-08-02 | — | — | CN | claimed |
| WO-2000037066-A2 | A METHOD FOR THE PROPHYLACTIC TREATMENT OF CATARACTS | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2000-06-29 | — | — | WO | claimed |
| EP-0991424-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING AN ALDOSE REDUCTASE INHIBITOR AND AN ACE INHIBITOR | ZENECA LIMITED (GB) | 2000-04-12 | — | — | EP | claimed |
| WO-1999002189-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING AN ALDOSE REDUCTASE INHIBITOR AND AN ACE INHIBITOR | ZENECA LIMITED (GB) | 1999-01-21 | — | — | WO | claimed |
| US-4734419-A | Quinazoline derivatives, compositions thereof and their use in treating diabetic complications | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-03-29 | — | — | US | claimed |
| EP-0218999-A2 | New quinazoline derivatives, process for their production and pharmaceutical compositions comprising them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-04-22 | — | — | EP | claimed |