Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 8/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.35 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4896004 | 1.00 | KCNH2 (0.43) | KCNH2HTR2AP2RY14AKT1ROCK2 | |
| SCHEMBL4896024 | 1.00 | KCNH2 (0.43) | KCNH2HTR2AP2RY14AKT1ROCK2 | |
| SCHEMBL26120963 | 0.85 | HTR2A (0.43) | HTR2AP2RY14AKT1HTR2CKDM1A | |
| SCHEMBL4889946 | 0.85 | KDM1A (0.52) | KCNH2HTR2AP2RY14AKT1HTR2C | |
| SCHEMBL23873193 | 0.85 | HTR2A (0.43) | HTR2AP2RY14AKT1HTR2CKDM1A | |
| SCHEMBL23873188 | 0.85 | HTR2A (0.43) | HTR2AP2RY14AKT1HTR2CKDM1A | |
| SCHEMBL4889938 | 0.85 | KDM1A (0.52) | KCNH2HTR2AP2RY14AKT1HTR2C | |
| SCHEMBL4889950 | 0.85 | KDM1A (0.52) | KCNH2HTR2AP2RY14AKT1HTR2C | |
| SCHEMBL23873175 | 0.82 | P2RY14 (0.42) | HTR2AP2RY14AKT1HTR2CKDM1A | |
| SCHEMBL23873176 | 0.82 | P2RY14 (0.42) | HTR2AP2RY14AKT1HTR2CKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080312271-A1 | AZABENZIMIDAZOLYL COMPOUNDS | PFIZER INC. | 2008-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312271-A1 | AZABENZIMIDAZOLYL COMPOUNDS | AZI2, PAICS, UGT2B7 | KCNH2 434/4885HTR2A 1378/4885P2RY14 1860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.