Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.70 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.70 |
| ▸ | CISD1 | Q9NZ45 | 4/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 9/20 | 0.38 |
| ▸ | CA2 | P00918 | 9/20 | 0.38 |
| ▸ | CA12 | O43570 | 7/20 | 0.38 |
| ▸ | CA9 | Q16790 | 7/20 | 0.38 |
| ▸ | CA7 | P43166 | 4/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 4/20 | 0.38 |
| ▸ | CA5A | P35218 | 3/20 | 0.38 |
| ▸ | CA6 | P23280 | 3/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Azosemide SCHEMBL4421865 | 1.00 | PDE4D (0.70) | PDE4DPDE3ACISD1POLBCA1 | |
| Azosemide SCHEMBL30754398 | 1.00 | PDE4D (0.70) | PDE4DPDE3ACISD1POLBCA1 | |
| Azosemide SCHEMBL8988688 | 0.99 | PDE4D (0.69) | PDE4DPDE3ACISD1POLBCA1 | |
| Azosemide SCHEMBL230626 | 0.93 | PDE4D (0.62) | PDE4DPDE3ACISD1POLBCA1 | |
| Azosemide SCHEMBL231405 | 0.90 | PDE4D (0.58) | PDE4DPDE3ACISD1POLBCA1 | |
| Azosemide SCHEMBL230300 | 0.89 | PDE4D (0.57) | PDE4DPDE3ACISD1POLBCA1 | |
| SCHEMBL11929680 | 0.89 | PDE4D (0.55) | PDE4DPDE3ACISD1POLBALDH1A1 | |
| SCHEMBL12522802 | 0.88 | PDE4D (0.55) | PDE4DPDE3ACISD1ALDH1A1PTGS2 | |
| SCHEMBL10281116 | 0.87 | PDE4D (0.54) | PDE4DPDE3ACISD1POLBALDH1A1 | |
| SCHEMBL14513929 | 0.87 | PDE4D (0.53) | PDE4DPDE3ACISD1POLBCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 5440 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4719435-A2 | COMPOSITIONS TO TREAT OBESITY BY TARGETING KCC2 AND NKCC1 | The Jackson Laboratory (US) | 2026-04-08 | — | — | EP | claimed |
| US-20250275987-A1 | MODULATORS OF INTRACELLULAR CHLORIDE CONCENTRATION FOR USE IN THE TREATMENT OF COGNITIVE DECLINE | FONDAZIONE ISTITUTO ITALIANO DI TECHNOLOGIA (IT) | 2025-09-04 | — | — | US | claimed |
| US-20250221991-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CANCER METASTASES | UNIVERSITY OF CINCINNATI (US) | 2025-07-10 | — | — | US | claimed |
| WO-2025101947-A1 | MULTIPLEXED TARGETED PEPTIDE QUANTITATION | Astrin Biosciences, Inc. (US) | 2025-05-15 | — | — | WO | claimed |
| US-20250057876-A1 | METHODS FOR TREATING AND/OR PREVENTING LYMPHANGIOGENESIS-ASSOCIATED DISEASES BY USING GOLD NANOCLUSTERS | GOLDRED NANOBIOTECH CO., LTD. (TW) | 2025-02-20 | — | — | US | claimed |
| WO-2024243538-A2 | METHODS AND COMPOSITIONS TO TREAT OBESITY BY TARGETING KCC2 AND NKCC1 | THE JACKSON LABORATORY (US) | 2024-11-28 | — | — | WO | claimed |
| EP-3419612-B1 | HETEROCYCLIC SMALL MOLECULE INHIBITORS OF PENDRIN ION EXCHANGE AND PHARMACEUTICAL COMPOSITIONS | UNIV CALIFORNIA (US) | 2024-11-06 | — | — | EP | claimed |
| EP-4311548-A1 | COMBINATION OF A NKCC1 PROTEIN INHIBITOR AND A MICROTUBULE INHIBITOR FOR USE IN THE TREATMENT OF CANCER | B & A Therapeutics (FR) | 2024-01-31 | — | — | EP | claimed |
| US-20240002935-A1 | GENETIC METHOD FOR DIAGNOSIS AND TREATMENT OF PRE AND POST CORONAVIRUS INFECTIONS | GENETICURE INC. | 2024-01-04 | — | — | US | claimed |
| WO-2023230770-A1 | METHODS OF LUNG ADENOCARCINOMA TREATMENT WITH NON ANTI-LUAD DRUGS OR COMPOUNDS | Suzhou Singleron Biotechnologies Co., Ltd. (CN) | 2023-12-07 | — | — | WO | claimed |
| EP-0753301-A1 | Combination of benzimidazoles having angiotensin-II antagonistic activity with diuretics | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-01-15 | — | — | EP | claimed |
| US-5504099-A | STORAGE STABLE AQUEOUS DIURETIC SOLUTION CONTAINING AZOSEMIDE SALT OF ORGANIC AMINE AND BIOCOMPATIBLE ORGANIC SOLVENT | BOEHRINGER MANNHEIM GMBH (DE) | 1996-04-02 | — | — | US | claimed |
| EP-0643580-A4 | COMBINATIONS OF ACE INHIBITORS AND DIURETICS. | — | 1995-04-19 | — | — | EP | claimed |
| EP-0643580-A1 | COMBINATIONS OF ACE INHIBITORS AND DIURETICS | MERCK & CO. INC. (US) | 1995-03-22 | — | — | EP | claimed |
| EP-0628313-A1 | Combination of benzimidazoles having angiotensin-II antagonistic activity with dinretics or calcium antagonists | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-12-14 | — | — | EP | claimed |
| WO-1994009778-A1 | COMBINATIONS OF ANGIOTENSIN-II RECEPTOR ANTAGONISTS AND DIURETICS | MERCK & CO., INC. (US) | 1994-05-11 | — | — | WO | claimed |
| WO-1993017685-A1 | COMBINATIONS OF ACE INHIBITORS AND DIURETICS | MERCK & CO., INC. (US) | 1993-09-16 | — | — | WO | claimed |
| US-4088759-A | Injectable pharmaceutical solutions | BOEHRINGER MANNHEIM GMBH (DT) | 1978-05-09 | — | — | US | claimed |
| US-4031213-A | TETRAZOLE, STEROIDS | BOEHRINGER MANNHEIM G.M.B.H. (DT) | 1977-06-21 | — | — | US | claimed |
| US-3963834-A | A MIXTURE OF A TETRAZOLE, A PROPIONIC ACID LACTONE, AND AN ANDROSTADIEN-PROPIONIC ACID | BOEHRINGER MANNHEIM G.M.B.H. (DT) | 1976-06-15 | — | — | US | claimed |