Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 11/20 | 0.49 |
| ▸ | CCR6 | P51684 | 1/20 | 0.42 |
| ▸ | IDH1 | O75874 | 4/20 | 0.39 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.38 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 2/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.38 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.38 |
| ▸ | PRKX | P51817 | 1/20 | 0.38 |
| ▸ | NEK4 | P51957 | 1/20 | 0.38 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.38 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.38 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4903227 | 0.84 | MAPKAPK2 (0.49) | MAPKAPK2CCR6IDH1PLK1ROCK1 | |
| SCHEMBL4905183 | 0.76 | MAPKAPK2 (0.54) | MAPKAPK2IDH1PLK1ROCK1AURKB | |
| SCHEMBL4543440 | 0.74 | MAPKAPK2 (0.72) | MAPKAPK2PLK1ROCK1AURKBDCLK1 | |
| SCHEMBL4599142 | 0.73 | MAPKAPK2 (0.53) | MAPKAPK2IDH1PLK1ROCK1AURKB | |
| SCHEMBL4919825 | 0.72 | MAPKAPK2 (0.54) | MAPKAPK2CCR6CXCR1CXCR2PLK1 | |
| SCHEMBL4905505 | 0.71 | CXCR2 (0.41) | MAPKAPK2CXCR2ROCK1AURKBROCK2 | |
| SCHEMBL4914806 | 0.69 | MAPKAPK2 (0.55) | MAPKAPK2CCR6PLK1ROCK1AURKB | |
| SCHEMBL4915911 | 0.69 | MAPKAPK2 (0.55) | MAPKAPK2CCR6PLK1ROCK1AURKB | |
| SCHEMBL4362293 | 0.69 | MAPKAPK2 (0.68) | MAPKAPK2PLK1ROCK1AURKBDCLK1 | |
| SCHEMBL4905771 | 0.69 | MAPKAPK2 (0.55) | MAPKAPK2PLK1ROCK1AURKBDCLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234266-A1 | Squaric Acid Derivatives II | MERCK PATENT GESELLSCHAFT (DE) | 2008-09-25 | — | — | US | claimed |
| US-20080234266-A1 | Squaric Acid Derivatives II | MERCK PATENT GESELLSCHAFT (DE) | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234266-A1 | Squaric Acid Derivatives II | CHEK2, CHEK1, SGK3 | MAPKAPK2 346/4885CCR6 3339/4885IDH1 95/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.