Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 16/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.80 |
| ▸ | HTR2C | P28335 | 4/20 | 0.56 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4891759 | 0.98 | HDAC1 (0.96) | HDAC1KCNH2HTR2CMCHR1 | |
| SCHEMBL4896659 | 0.93 | HDAC1 (1.00) | HDAC1KCNH2HTR2CMCHR1HDAC3 | |
| SCHEMBL4898587 | 0.93 | HDAC1 (0.86) | HDAC1KCNH2HTR2CMCHR1HDAC3 | |
| SCHEMBL3617078 | 0.91 | HDAC1 (1.00) | HDAC1KCNH2HTR2CMCHR1HDAC3 | |
| SCHEMBL4898722 | 0.90 | HDAC1 (1.00) | HDAC1KCNH2HTR2CMCHR1HDAC3 | |
| SCHEMBL4901139 | 0.89 | HDAC1 (0.81) | HDAC1KCNH2HTR2CMCHR1HDAC3 | |
| SCHEMBL4893535 | 0.89 | HDAC1 (0.81) | HDAC1KCNH2HTR2CMCHR1HDAC3 | |
| SCHEMBL3622238 | 0.89 | HDAC1 (1.00) | HDAC1KCNH2HTR2CMCHR1HDAC3 | |
| SCHEMBL3615514 | 0.87 | HDAC1 (0.96) | HDAC1KCNH2HTR2CMCHR1HDAC3 | |
| SCHEMBL4901200 | 0.86 | HDAC1 (0.76) | HDAC1KCNH2HTR2CMCHR1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080119451-A1 | Novel Benzamide Derivatives | ASTRAZENECA AB (SE) | 2008-05-22 | — | — | US | claimed |
| WO-2006077387-A2 | NOVEL BENZAMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2006-07-27 | — | — | WO | claimed |
| US-20080119451-A1 | Novel Benzamide Derivatives | ASTRAZENECA AB (SE) | 2008-05-22 | — | — | US | disclosed |
| US-20080119451-A1 | Novel Benzamide Derivatives | ASTRAZENECA AB (SE) | 2008-05-22 | — | — | US | disclosed |
| US-20080119451-A1 | Novel Benzamide Derivatives | ASTRAZENECA AB (SE) | 2008-05-22 | — | — | US | disclosed |
| WO-2006077387-A2 | NOVEL BENZAMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2006-07-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119451-A1 | Novel Benzamide Derivatives | HDAC1, HDAC11, HDAC2 | HDAC1 1/4885KCNH2 1230/4885HTR2C 2593/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.