Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | CASP1 | P29466 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | RORB | Q92753 | 2/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5654518 | 0.92 | KDM4E (0.55) | KDM4EHSD17B10MEN1KMT2ACASP1 | |
| SCHEMBL3552671 | 0.92 | KDM4E (0.55) | KDM4EHSD17B10MEN1KMT2ACASP1 | |
| SCHEMBL3559250 | 0.92 | KDM4E (0.55) | KDM4EHSD17B10MEN1KMT2ACASP1 | |
| SCHEMBL3556688 | 0.89 | MEN1 (0.52) | KDM4EHSD17B10MEN1KMT2ACASP1 | |
| SCHEMBL5550324 | 0.86 | KDM4E (0.51) | KDM4EHSD17B10MEN1KMT2ACASP1 | |
| SCHEMBL5658015 | 0.85 | NPSR1 (0.50) | KDM4EHSD17B10MEN1KMT2ACASP1 | |
| SCHEMBL5023770 | 0.85 | KDM4E (0.52) | KDM4EHSD17B10MEN1KMT2ACASP1 | |
| SCHEMBL1538310 | 0.80 | MEN1 (0.59) | KDM4EMEN1KMT2AHPGDMAPK1 | |
| SCHEMBL5026927 | 0.79 | MEN1 (0.65) | KDM4EHSD17B10MEN1KMT2ACASP1 | |
| SCHEMBL14039064 | 0.77 | CSNK2A2 (0.47) | KDM4EKMT2APDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8329714-B2 | Farnesyl transferase inhibiting 1,2-annelated quinoline enantiomer | JANSSEN PHARMACEUTICA NV (BE) | 2012-12-11 | — | — | US | disclosed |
| US-8318753-B2 | (-)-5-(3-Chlorophenyl)- alpha -(4-chlorophenyl)- alpha -(1-methyl-1H-imidazol-5-yl)tetrazolo-[1,5-a]quinazoline-7-methanamine and its pharmaceutically acceptable acid addition salts; anticancer agent | JANSSEN PHARMACEUTICA NV (BE) | 2012-11-27 | — | — | US | disclosed |
| US-20080114009-A1 | Farnesyl Transferase Inhibiting 1,2-Annelated Quinoline Enantiomer | VENET MARC GASTON | 2008-05-15 | — | — | US | disclosed |
| US-20070259902-A1 | FARNESYL TRANSFERASE INHIBITING 1,2-ANNELATED QUINOLINE ENANTIOMER | VENEL MARC G | 2007-11-08 | — | — | US | disclosed |
| EP-0977750-B1 | FARNESYLTRANSFERASE INHIBITING QUINAZOLINONES | JANSSEN PHARMACEUTICA NV (BE) | 2007-07-04 | — | — | EP | disclosed |
| US-7173040-B2 | Farnesyl transferase inhibiting 6-[(substituted phenyl)methyl]-quinoline and quinazoline derinazoline derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-02-06 | — | — | US | disclosed |
| EP-1296984-B1 | PHARMACEUTICAL COMPOSITION COMPRISING A FARNESYL TRANSFERASE INHIBITING 1,2-ANNELATED QUINOLINE ENANTIOMER | JANSSEN PHARMACEUTICA NV (BE) | 2005-05-04 | — | — | EP | disclosed |
| US-20040048882-A1 | Farnesyl transferase inhibiting 6-(substituted phenyl) Methy)-quinoline and quinazoline derinazoline derivaties | JANSSEN-CILAG S.A. (FR) | 2004-03-11 | — | — | US | disclosed |
| EP-1322636-A1 | FARNESYL TRANSFERASE INHIBITING 6- (SUBSTITUTED PHENYL)METHYL]-QUINOLINE AND QUINAZOLINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-07-02 | — | — | EP | disclosed |
| US-20030114471-A1 | Farnesyl transferase inhibiting 1,2-annelated quinoline enantiomer | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-06-19 | — | — | US | disclosed |
| EP-1296984-A1 | FARNESYL TRANSFERASE INHIBITING 1,2-ANNELATED QUINOLINE ENANTIOMER | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002024683-A1 | FARNESYL TRANSFERASE INHIBITING 6-[(SUBSTITUTED PHENYL)METHYL]-QUINOLINE AND QUINAZOLINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-03-28 | — | — | WO | disclosed |
| US-6358961-B1 | ADMINISTERING QUINAZOLINE DERIVATIVE FOR INHIBITING TUMOR GROWTH IN MAMMALS | JANNSEN-CILAG S.A. (FR) | 2002-03-19 | — | — | US | disclosed |
| WO-2001098302-A1 | FARNESYL TRANSFERASE INHIBITING 1,2-ANNELATED QUINOLINE ENANTIOMER | JANSSEN PHARMACEUTICA N.V. (BE) | 2001-12-27 | — | — | WO | disclosed |
| US-6177432-B1 | ANTICARCINOGENIC AGENTS, ANTITUMOR AGENTS | JANSSEN-CILAG S.A. (FR) | 2001-01-23 | — | — | US | disclosed |
| EP-0977750-A1 | FARNESYLTRANSFERASE INHIBITING QUINAZOLINONES | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-02-09 | — | — | EP | disclosed |
| WO-1998049157-A1 | FARNESYLTRANSFERASE INHIBITING QUINAZOLINONES | JANSSEN PHARMACEUTICA N.V. (BE) | 1998-11-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040048882-A1 | Farnesyl transferase inhibiting 6-(substituted phenyl) Methy)-quinoline and quinazoline derinazoline derivaties | FNTB, FNTA, CYP7A1 | KDM4E 1592/4885HSD17B10 639/4885MEN1 887/4885 |
| US-20030114471-A1 | Farnesyl transferase inhibiting 1,2-annelated quinoline enantiomer | FNTB, FNTA, CYP7A1 | KDM4E 3515/4885HSD17B10 346/4885MEN1 596/4885 |
| US-20070259902-A1 | FARNESYL TRANSFERASE INHIBITING 1,2-ANNELATED QUINOLINE ENANTIOMER | FNTA, FNTB, CYP7A1 | KDM4E 3278/4885HSD17B10 496/4885MEN1 593/4885 |
| US-20080114009-A1 | Farnesyl Transferase Inhibiting 1,2-Annelated Quinoline Enantiomer | FNTA, FNTB, CYP7A1 | KDM4E 3278/4885HSD17B10 496/4885MEN1 593/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.