Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Benzbromarone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 known ✓ | Q96S37 | 7/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 7/20 | 1.00 |
| ▸ | EYA3 | Q99504 | 6/20 | 1.00 |
| ▸ | TTR | P02766 | 4/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 4/20 | 1.00 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | PGR | P06401 | 2/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 2/20 | 1.00 |
| ▸ | TBXA2R | P21731 | 2/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 2/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | EYA2 | O00167 | 1/20 | 1.00 |
| ▸ | ABCC4 | O15439 | 1/20 | 1.00 |
| ▸ | PLIN1 | O60240 | 1/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | USP2 | O75604 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzbromarone SCHEMBL29361528 | 1.00 | SLC22A12 (1.00) | SLC22A12CYP2C19EYA3TTRCYP2C9 | |
| Benzbromarone SCHEMBL19205474 | 1.00 | SLC22A12 (1.00) | SLC22A12CYP2C19EYA3TTRCYP2C9 | |
| Benzbromarone SCHEMBL6761161 | 0.96 | SLC22A12 (0.93) | SLC22A12CYP2C19EYA3TTRCYP2C9 | |
| SCHEMBL19235987 | 0.93 | CYP2C19 (0.86) | SLC22A12CYP2C19EYA3TTRCYP2C9 | |
| SCHEMBL20376048 | 0.92 | CYP2C19 (0.84) | SLC22A12CYP2C19EYA3TTRCYP2C9 | |
| SCHEMBL18058593 | 0.90 | CYP2C19 (0.81) | SLC22A12CYP2C19EYA3TTRCYP2C9 | |
| SCHEMBL29286592 | 0.89 | CYP2C19 (0.79) | SLC22A12CYP2C19EYA3TTRCYP2C9 | |
| SCHEMBL1287644 | 0.88 | TTR (1.00) | SLC22A12CYP2C19EYA3TTRCYP2C9 | |
| SCHEMBL1287583 | 0.87 | CYP2C19 (0.77) | SLC22A12CYP2C19EYA3TTRCYP2C9 | |
| SCHEMBL1287909 | 0.86 | CYP2C19 (1.00) | SLC22A12CYP2C19EYA3TTRCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 8884 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260130854-A1 | PREPARATION OF NANO LINIMENT FOR EXTERNAL TREATMENT OF GOUT | Zhang, Boke (US) | 2026-05-14 | — | — | US | claimed |
| US-20260130853-A1 | METHOD OF TREATING GOUT BY TOPICAL APPLICATION OF NANO LINIMENT | Zhang, Boke (US) | 2026-05-14 | — | — | US | claimed |
| EP-4731204-A2 | SELECTIVE RBP4 ANTAGONIST AND C20-D3-RETINOL FOR TREATING MACULAR DEGENERATION, NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD), AND GOUTY ARTHRITIS (GOUT) | The Trustees Of Columbia University In The City Of New York (US) | 2026-04-29 | — | — | EP | claimed |
| US-12539273-B2 | External nano liniment for gout and preparation method thereof | Zhang, Boke (US) | 2026-02-03 | — | — | US | claimed |
| US-20260027337-A1 | TRANSDERMAL DRUG DELIVERY DEVICES AND METHODS | MORNINGSIDE VENTURE INVESTMENTS LTD (MC) | 2026-01-29 | — | — | US | claimed |
| EP-4680240-A1 | METHOD OF TREATING DISORDERS WITH SURF1 MALFUNCTION | Cure Mito Foundation (US) | 2026-01-21 | — | — | EP | claimed |
| US-12515030-B2 | Transdermal drug delivery devices and methods | MORNINGSIDE VENTURE INVESTMENTS LIMITED (MC) | 2026-01-06 | — | — | US | claimed |
| US-20260000663-A1 | RBP4 ANTAGONISTS FOR TREATMENT AND PREVENTION OF NON-ALCOHOLIC FATTY LIVER DISEASE AND GOUT | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2026-01-01 | — | — | US | claimed |
| EP-4633622-A2 | COMPOSITIONS AND METHODS FOR REGULATING PROCOAGULANT ACTIVITY AND THROMBOSIS | Beth Israel Deaconess Medical Center, Inc. (US) | 2025-10-22 | — | — | EP | claimed |
| US-12440486-B2 | RBP4 antagonists for treatment and prevention of non-alcoholic fatty liver disease and gout | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2025-10-14 | — | — | US | claimed |
| US-5700410-A | Method of manufacturing wax matrices | NIPPON SHINYAKU CO., LTD. (JP) | 1997-12-23 | — | — | US | claimed |
| EP-0695172-B1 | HIGH RELEASE SOLID PREPARATION, PREPARATION AND USE THEREOF | UNIV GENT (BE) | 1997-12-17 | — | — | EP | claimed |
| EP-0580860-B1 | METHOD OF MANUFACTURING SOLID DISPERSION | NIPPON SHINYAKU CO LTD (JP) | 1997-10-22 | — | — | EP | claimed |
| EP-0617612-B1 | A PROCESS FOR THE PREPARATION OF A SOLID DISPERSION | WARNER LAMBERT CO (US) | 1997-09-10 | — | — | EP | claimed |
| EP-0695172-A1 | HIGH RELEASE SOLID PREPARATION, PREPARATION AND USE THEREOF | RIJKSUNIVERSITEIT GENT LABORATORIUM VOOR FARMACEUTISCHE TECHNOLOGIE (BE) | 1996-02-07 | — | — | EP | claimed |
| WO-1994023700-A1 | HIGH RELEASE SOLID PREPARATION, PREPARATION AND USE THEREOF | RIJKSUNIVERSITEIT GENT LABORATORIUM VOOR FARMACEUTISCHE TECHNOLOGIE (BE) | 1994-10-27 | — | — | WO | claimed |
| EP-0617612-A1 | A PROCESS FOR THE PREPARATION OF A SOLID DISPERSION. | WARNER LAMBERT CO (US) | 1994-10-05 | — | — | EP | claimed |
| US-5288503-A | WATER-PERMEABLE DIFFUSION BARRIER OF POLYVINYL ALCOHOL | SRCHEM INCORPORATED (US) | 1994-02-22 | — | — | US | claimed |
| US-5260066-A | Cryogel bandage containing therapeutic agent | SRCHEM INCORPORATED (US) | 1993-11-09 | — | — | US | claimed |
| WO-1993011749-A1 | A PROCESS FOR THE PREPARATION OF A SOLID DISPERSION | WARNER-LAMBERT COMPANY (US) | 1993-06-24 | — | — | WO | claimed |