Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 3/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 8/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 5/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | PTPRC | P08575 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | WDR5 | P61964 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4898665 | 0.93 | PTPN1 (0.39) | MAPK10PTPN1ALDH1A1PTPN2PTPRC | |
| SCHEMBL4903704 | 0.91 | MAPK10 (0.42) | MAPK10PTPN1ALDH1A1PTPN2NOTUM | |
| SCHEMBL4901328 | 0.91 | MAPK10 (0.42) | MAPK10PTPN1ALDH1A1PTPN2NOTUM | |
| SCHEMBL4900018 | 0.91 | MAPK10 (0.40) | MAPK10PTPN1ALDH1A1PTPN2NOTUM | |
| SCHEMBL14257149 | 0.91 | MAPK10 (0.40) | MAPK10PTPN1ALDH1A1PTPN2NOTUM | |
| SCHEMBL4895547 | 0.90 | MAPK8 (0.43) | MAPK10PTPN1ALDH1A1PTPN2NOTUM | |
| SCHEMBL4890553 | 0.90 | PTPN1 (0.40) | MAPK10PTPN1ALDH1A1PTPN2NOTUM | |
| SCHEMBL4899310 | 0.88 | PTPN1 (0.38) | MAPK10PTPN1ALDH1A1PTPN2NOTUM | |
| SCHEMBL4894157 | 0.88 | MAPK10 (0.38) | MAPK10PTPN1ALDH1A1PTPN2NOTUM | |
| SCHEMBL4891987 | 0.86 | PTPN1 (0.40) | MAPK10PTPN1ALDH1A1PTPN2NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080070867-A1 | 2-Imidazolone and 2-Imidazolidinone Heterocyclic Inhibitors of Tyrosine Phosphatases | METABASIS THERAPEUTICS, INC. (US) | 2008-03-20 | — | — | US | claimed |
| US-20080070867-A1 | 2-Imidazolone and 2-Imidazolidinone Heterocyclic Inhibitors of Tyrosine Phosphatases | METABASIS THERAPEUTICS, INC. (US) | 2008-03-20 | — | — | US | disclosed |
| US-20080070867-A1 | 2-Imidazolone and 2-Imidazolidinone Heterocyclic Inhibitors of Tyrosine Phosphatases | METABASIS THERAPEUTICS, INC. (US) | 2008-03-20 | — | — | US | disclosed |
| US-20080070867-A1 | 2-Imidazolone and 2-Imidazolidinone Heterocyclic Inhibitors of Tyrosine Phosphatases | METABASIS THERAPEUTICS, INC. (US) | 2008-03-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080070867-A1 | 2-Imidazolone and 2-Imidazolidinone Heterocyclic Inhibitors of Tyrosine Phosphatases | PPM1B, PPM1D, PTPRS | MAPK10 656/4885PTPN1 13/4885ALDH1A1 3704/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.