Sugi Predict

Sugi Predict / Compounds / SCHEMBL4901271

SCHEMBL4901271

SCHEMBL4901271

O=C(O)c1ccc(-c2cn(Cc3ccccn3)c(=O)n2Cc2ccc(C(F)(F)P(=O)(O)O)c(Br)c2)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PTPN1 P18031 8/20 0.41
▸ PTPN2 P17706 5/20 0.41
▸ PTPRC P08575 1/20 0.39
▸ KDM4E B2RXH2 1/20 0.35
▸ KDM4C Q9H3R0 1/20 0.34
▸ F11 P03951 1/20 0.33
▸ KLKB1 P03952 1/20 0.33
▸ PPARG P37231 1/20 0.33
▸ PTGER4 P35408 1/20 0.33
▸ EPHX2 P34913 1/20 0.33
▸ MARS1 P56192 1/20 0.33
▸ SLC16A3 O15427 1/20 0.33
▸ MEN1 O00255 1/20 0.33
▸ MAPT P10636 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ HDAC3 O15379 1/20 0.33
▸ HDAC4 P56524 1/20 0.33
▸ HDAC1 Q13547 1/20 0.33
▸ HDAC7 Q8WUI4 1/20 0.33
▸ HDAC2 Q92769 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4892827 0.91 PTPN1 (0.38) PTPN1PTPN2PTPRCPPARG
SCHEMBL4898664 0.89 PTPN1 (0.45) PTPN1PTPN2PTPRCPTGER4HDAC1
SCHEMBL4895481 0.89 PTPN1 (0.45) PTPN1PTPN2PTPRCPTGER4HDAC1
SCHEMBL4901303 0.88 PTPN1 (0.46) PTPN1PTPN2PTPRCPTGER4
SCHEMBL4889729 0.86 PTPN1 (0.42) PTPN1PTPN2PTPRCKDM4EPTGER4
SCHEMBL4898619 0.85 PTPN1 (0.43) PTPN1PTPN2PTPRCKDM4EHDAC1
SCHEMBL4901272 0.83 KDM4E (0.35) KDM4EKDM4CPPARGEPHX2MARS1
SCHEMBL4899255 0.83 PTPN1 (0.44) PTPN1PTPN2PTPRCHDAC1HDAC11
SCHEMBL4898665 0.82 PTPN1 (0.39) PTPN1PTPN2PTPRCPTGER4
SCHEMBL4898515 0.82 PTPN1 (0.45) PTPN1PTPN2PTPRCPTGER4HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080070867-A1 2-Imidazolone and 2-Imidazolidinone Heterocyclic Inhibitors of Tyrosine Phosphatases METABASIS THERAPEUTICS, INC. (US) 2008-03-20 — — US claimed
WO-2006078698-A1 2-IMIDAZOLONE AND 2-IMIDAZOLIDINONE HETEROCYCLIC INHIBITORS OF TYROSINE PHOSPHATASES CENGENT THERAPEUTICS, INC. (US) 2006-07-27 — — WO claimed
US-20080070867-A1 2-Imidazolone and 2-Imidazolidinone Heterocyclic Inhibitors of Tyrosine Phosphatases METABASIS THERAPEUTICS, INC. (US) 2008-03-20 — — US disclosed
US-20080070867-A1 2-Imidazolone and 2-Imidazolidinone Heterocyclic Inhibitors of Tyrosine Phosphatases METABASIS THERAPEUTICS, INC. (US) 2008-03-20 — — US disclosed
US-20080070867-A1 2-Imidazolone and 2-Imidazolidinone Heterocyclic Inhibitors of Tyrosine Phosphatases METABASIS THERAPEUTICS, INC. (US) 2008-03-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080070867-A1 2-Imidazolone and 2-Imidazolidinone Heterocyclic Inhibitors of Tyrosine Phosphatases PPM1B, PPM1D, PTPRS PTPN1 13/4885PTPN2 27/4885PTPRC 18/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.