Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 12/20 | 0.43 |
| ▸ | CDK2 | P24941 | 7/20 | 0.43 |
| ▸ | SGK1 | O00141 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.34 |
| ▸ | AKT3 | Q9Y243 | 4/20 | 0.33 |
| ▸ | PRKACA | P17612 | 2/20 | 0.33 |
| ▸ | PRKACG | P22612 | 2/20 | 0.33 |
| ▸ | PRKACB | P22694 | 2/20 | 0.33 |
| ▸ | AKT2 | P31751 | 2/20 | 0.33 |
| ▸ | SRC | P12931 | 2/20 | 0.33 |
| ▸ | PRKCG | P05129 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 2/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | PRKCA | P17252 | 1/20 | 0.33 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4781683 | 0.92 | AKT1 (0.41) | AKT1CDK2SGK1ROCK2AKT3 | |
| SCHEMBL4781687 | 0.92 | AKT1 (0.41) | AKT1CDK2SGK1ROCK2AKT3 | |
| SCHEMBL4891438 | 0.87 | AKT1 (0.49) | AKT1CDK2SGK1ROCK2AKT3 | |
| SCHEMBL4895923 | 0.87 | AKT1 (0.49) | AKT1CDK2SGK1ROCK2AKT3 | |
| SCHEMBL4892503 | 0.81 | AKT1 (0.46) | AKT1CDK2SGK1ROCK2AKT3 | |
| SCHEMBL14260957 | 0.79 | AKT1 (0.44) | AKT1CDK2SGK1ROCK2AKT3 | |
| SCHEMBL4781235 | 0.78 | AKT1 (0.45) | AKT1CDK2SGK1PRKACA | |
| SCHEMBL4781239 | 0.78 | AKT1 (0.45) | AKT1CDK2SGK1PRKACA | |
| SCHEMBL4781775 | 0.78 | AKT1 (0.45) | AKT1CDK2SGK1PRKACA | |
| SCHEMBL1600571 | 0.76 | AKT1 (0.69) | AKT1CDK2SGK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080242694-A1 | Amino-substituted heterocycles, compositions thereof, and methods of treatment therewith | D SIDOCKY NEIL R | 2008-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242694-A1 | Amino-substituted heterocycles, compositions thereof, and methods of treatment therewith | JAK2, CHEK2, MTOR | AKT1 26/4885CDK2 64/4885SGK1 467/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.