Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 5/20 | 0.55 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.55 |
| ▸ | RXRA | P19793 | 3/20 | 0.55 |
| ▸ | CCR2 | P41597 | 3/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 2/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | F3 | P13726 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4910419 | 1.00 | NR1H2 (0.55) | NR1H2NR1H3RXRACCR2CTSL | |
| SCHEMBL2389393 | 0.95 | NR1H2 (0.54) | NR1H2NR1H3RXRACCR2CTSL | |
| SCHEMBL2387101 | 0.95 | NR1H2 (0.54) | NR1H2NR1H3RXRACCR2CTSL | |
| SCHEMBL2387095 | 0.95 | NR1H2 (0.54) | NR1H2NR1H3RXRACCR2CTSL | |
| SCHEMBL2389496 | 0.93 | NR1H2 (0.56) | NR1H2NR1H3RXRACCR2ALDH1A1 | |
| SCHEMBL4908631 | 0.93 | NR1H2 (0.56) | NR1H2NR1H3RXRACCR2ALDH1A1 | |
| SCHEMBL2389581 | 0.88 | NR1H2 (0.57) | NR1H2NR1H3RXRACCR2MMP13 | |
| SCHEMBL2388715 | 0.88 | NR1H2 (0.52) | NR1H2NR1H3RXRACCR2ALDH1A1 | |
| SCHEMBL2388724 | 0.88 | NR1H2 (0.52) | NR1H2NR1H3RXRACCR2ALDH1A1 | |
| SCHEMBL2390392 | 0.88 | NR1H2 (0.52) | NR1H2NR1H3RXRACCR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080119488-A1 | Modulators Of Nuclear Receptors | EXELIXIS, INC. (US) | 2008-05-22 | — | — | US | disclosed |
| EP-1773337-A2 | MODULATORS OF NUCLEAR RECEPTORS | Exelixis, Inc. (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006025979-A9 | MODULATORS OF NUCLEAR RECEPTORS | EXELIXIS INC (US) | 2006-04-20 | — | — | WO | disclosed |
| WO-2006025979-A2 | MODULATORS OF NUCLEAR RECEPTORS | EXELIXIS, INC. (US) | 2006-03-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119488-A1 | Modulators Of Nuclear Receptors | NR1H2, NR0B1, NR1H3 | NR1H2 1/4885NR1H3 3/4885RXRA 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.