Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | CCR1 | P32246 | 3/20 | 0.59 |
| ▸ | CCR5 | P51681 | 3/20 | 0.59 |
| ▸ | CCR8 | P51685 | 3/20 | 0.59 |
| ▸ | TP53 | P04637 | 3/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | ALPL | P05186 | 1/20 | 0.59 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.59 |
| ▸ | ALPI | P09923 | 1/20 | 0.59 |
| ▸ | ALPG | P10696 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | METAP1 | P53582 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4896587 | 0.87 | KDM4E (0.43) | KDM4EL3MBTL1LMNACCR1CCR5 | |
| SCHEMBL4904986 | 0.87 | CYP2D6 (0.50) | KDM4EL3MBTL1LMNACCR1CCR5 | |
| SCHEMBL29125638 | 0.85 | KDM4E (0.63) | KDM4EL3MBTL1LMNACCR1CCR5 | |
| SCHEMBL4468554 | 0.83 | KDM4E (0.50) | KDM4EL3MBTL1LMNACCR1CCR5 | |
| SCHEMBL231127 | 0.82 | CYP2D6 (0.57) | KDM4EL3MBTL1LMNACCR1CCR5 | |
| SCHEMBL29074199 | 0.81 | KDM4E (0.49) | KDM4EL3MBTL1LMNACCR1CCR5 | |
| Hydrochloric Acid SCHEMBL6775520 | 0.80 | CYP2D6 (0.55) | KDM4EL3MBTL1LMNACCR1CCR5 | |
| Methane SCHEMBL28533749 | 0.80 | CYP2D6 (0.55) | KDM4EL3MBTL1LMNACCR1CCR5 | |
| Hydrochloric Acid SCHEMBL4902943 | 0.80 | KDM4E (0.61) | KDM4EL3MBTL1LMNACCR1CCR5 | |
| SCHEMBL230942 | 0.80 | GRM5 (0.47) | KDM4EL3MBTL1LMNACCR1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080108600-A1 | Polycyclic Pyridines as Potassium Ion Channel Modulators | ICAGEN, INC. (US) | 2008-05-08 | — | — | US | disclosed |
| EP-1737852-A2 | POLYCYCLIC PYRIDINES AS POTASSIUM ION CHANNEL MODULATORS | Icagen, Inc. (US) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005100349-A2 | POLYCYCLIC PYRIDINES AS POTASSIUM ION CHANNEL MODULATORS | ICAGEN, INC. (US) | 2005-10-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108600-A1 | Polycyclic Pyridines as Potassium Ion Channel Modulators | KCNJ2, KCNH2, KCNQ1 | KDM4E 542/4885L3MBTL1 3704/4885LMNA 3338/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.