Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 17/20 | 0.50 |
| ▸ | HSP90AB1 | P08238 | 16/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.50 |
| ▸ | CDC37 | Q16543 | 1/20 | 0.43 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.37 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3745457 | 0.93 | HSP90AA1 (0.50) | HSP90AA1HSP90AB1ERBB2CDC37HSP90B1 | |
| SCHEMBL1858420 | 0.86 | HSP90AA1 (0.50) | HSP90AA1HSP90AB1ERBB2 | |
| SCHEMBL13845812 | 0.86 | HSP90AB1 (0.37) | HSP90AA1HSP90AB1ERBB2HSP90B1TRAP1 | |
| SCHEMBL3122649 | 0.86 | HSP90AB1 (0.50) | HSP90AA1HSP90AB1ERBB2CDC37HSP90B1 | |
| SCHEMBL30599262 | 0.86 | HSP90AB1 (0.50) | HSP90AA1HSP90AB1ERBB2CDC37HSP90B1 | |
| SCHEMBL14067096 | 0.86 | HSP90AA1 (0.43) | HSP90AA1HSP90AB1ERBB2HSP90B1TRAP1 | |
| SCHEMBL1861838 | 0.83 | HSP90AA1 (0.69) | HSP90AA1HSP90AB1ERBB2HSP90B1TRAP1 | |
| SCHEMBL11980469 | 0.83 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1ERBB2HSP90B1TRAP1 | |
| SCHEMBL3524045 | 0.83 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1ERBB2HSP90B1TRAP1 | |
| SCHEMBL4896589 | 0.81 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1CDC37 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234297-A1 | HSP90 Inhibitors Containing a Zinc Binding Moiety | CURIS, INC. | 2008-09-25 | — | — | US | disclosed |
| US-20080221132-A1 | Multi-Functional Small Molecules as Anti-Proliferative Agents | CURIS, INC. | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221132-A1 | Multi-Functional Small Molecules as Anti-Proliferative Agents | HDAC1, HDAC6, HDAC5 | HSP90AA1 417/4885HSP90AB1 157/4885ERBB2 2794/4885 |
| US-20080234297-A1 | HSP90 Inhibitors Containing a Zinc Binding Moiety | HSP90AB1, HSP90AB2P, HSP90B1 | HSP90AA1 4/4885HSP90AB1 1/4885ERBB2 2208/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.