Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 5/20 | 0.92 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.92 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.92 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.92 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.92 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.92 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.92 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.92 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.92 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.92 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.92 |
| ▸ | BCL2L1 | Q07817 | 14/20 | 0.89 |
| ▸ | BCL2 | P10415 | 8/20 | 0.89 |
| ▸ | MDM4 | O15151 | 1/20 | 0.89 |
| ▸ | BCL2L11 | O43521 | 1/20 | 0.89 |
| ▸ | TP53 | P04637 | 1/20 | 0.89 |
| ▸ | BID | P55957 | 1/20 | 0.89 |
| ▸ | BAX | Q07812 | 1/20 | 0.89 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.89 |
| ▸ | ASPH | Q12797 | 1/20 | 0.89 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1540348 | 1.00 | HDAC3 (0.92) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL3955717 | 1.00 | HDAC3 (0.92) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL4740327 | 0.96 | HDAC3 (1.00) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL4740332 | 0.96 | HDAC3 (1.00) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1541049 | 0.96 | HDAC3 (0.90) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL3957570 | 0.96 | HDAC3 (0.93) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL4892842 | 0.96 | HDAC3 (0.93) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL14067155 | 0.95 | HDAC3 (0.89) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1540180 | 0.95 | BCL2L1 (0.90) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL19503787 | 0.94 | BCL2L1 (0.89) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080221132-A1 | Multi-Functional Small Molecules as Anti-Proliferative Agents | CURIS, INC. | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221132-A1 | Multi-Functional Small Molecules as Anti-Proliferative Agents | HDAC1, HDAC6, HDAC5 | HDAC3 7/4885HDAC4 5/4885HDAC1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.