Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 12/20 | 0.51 |
| ▸ | CDK2 | P24941 | 12/20 | 0.47 |
| ▸ | PIM1 | P11309 | 5/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 4/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.37 |
| ▸ | CDC7 | O00311 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.37 |
| ▸ | PRKACA | P17612 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.37 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4895589 | 0.93 | AKT1 (0.47) | AKT1CDK2PIM1PIM3PIM2 | |
| SCHEMBL4900504 | 0.93 | AKT1 (0.47) | AKT1CDK2PIM1PIM3PIM2 | |
| SCHEMBL4900303 | 0.89 | AKT1 (0.51) | AKT1CDK2PIM1PIM3PIM2 | |
| SCHEMBL4900218 | 0.89 | AKT1 (0.51) | AKT1CDK2PIM1PIM3PIM2 | |
| SCHEMBL4895583 | 0.87 | AKT1 (0.47) | AKT1CDK2PIM1PIM3PIM2 | |
| SCHEMBL4900499 | 0.87 | AKT1 (0.47) | AKT1CDK2PIM1PIM3PIM2 | |
| SCHEMBL4901166 | 0.84 | AKT1 (0.44) | AKT1CDK2PIM1PIM3PIM2 | |
| SCHEMBL4901159 | 0.84 | AKT1 (0.44) | AKT1CDK2PIM1PIM3PIM2 | |
| SCHEMBL1600857 | 0.83 | AKT1 (0.73) | AKT1CDK2 | |
| SCHEMBL1600854 | 0.83 | AKT1 (0.73) | AKT1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080242694-A1 | Amino-substituted heterocycles, compositions thereof, and methods of treatment therewith | D SIDOCKY NEIL R | 2008-10-02 | — | — | US | disclosed |
| US-20080242694-A1 | Amino-substituted heterocycles, compositions thereof, and methods of treatment therewith | D SIDOCKY NEIL R | 2008-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242694-A1 | Amino-substituted heterocycles, compositions thereof, and methods of treatment therewith | JAK2, CHEK2, MTOR | AKT1 26/4885CDK2 64/4885PIM1 914/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.