Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 16/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 3/20 | 0.42 |
| ▸ | HTR2C | P28335 | 3/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14458780 | 0.90 | MCHR1 (0.48) | MCHR1KCNH2HTR2AHTR2CHTR2B | |
| SCHEMBL1930352 | 0.90 | MCHR1 (0.43) | MCHR1KCNH2HTR2AHTR2CHTR2B | |
| SCHEMBL12532018 | 0.86 | MCHR1 (0.47) | MCHR1KCNH2HTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL1928535 | 0.85 | MCHR1 (0.47) | MCHR1KCNH2HTR2AHTR2CHTR2B | |
| SCHEMBL1928022 | 0.84 | MCHR1 (0.49) | MCHR1KCNH2HTR2AHTR2C | |
| SCHEMBL1930223 | 0.84 | MCHR1 (0.51) | MCHR1KCNH2HTR2AHTR2CHTR2B | |
| Trifluoroacetic Acid SCHEMBL1929462 | 0.84 | MCHR1 (0.57) | MCHR1KCNH2HTR2AHTR2CHTR2B | |
| SCHEMBL12531954 | 0.83 | MCHR1 (0.62) | MCHR1KCNH2HTR2AHTR2CHTR2B | |
| Trifluoroacetic Acid SCHEMBL1931079 | 0.83 | MCHR1 (0.52) | MCHR1KCNH2HTR2AHTR2CHTR2B | |
| Trifluoroacetic Acid SCHEMBL1930599 | 0.83 | MCHR1 (0.45) | MCHR1KCNH2HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1987039-A2 | MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS | Brystol-Myers Squibb Company (US) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007092416-A2 | MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-08-16 | — | — | WO | disclosed |