Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 15/20 | 0.55 |
| ▸ | IKBKB | O14920 | 3/20 | 0.49 |
| ▸ | JAK2 | O60674 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL490634 | 0.84 | CHEK1 (0.64) | CHEK1IKBKBJAK2MEN1EIF2AK2 | |
| SCHEMBL491117 | 0.83 | CHEK1 (0.61) | CHEK1IKBKBJAK2MEN1EIF2AK2 | |
| SCHEMBL2453429 | 0.83 | CHEK1 (0.61) | CHEK1IKBKBJAK2MEN1EIF2AK2 | |
| SCHEMBL491200 | 0.83 | IKBKB (0.58) | CHEK1IKBKBJAK2MEN1EIF2AK2 | |
| SCHEMBL2456913 | 0.82 | CHEK1 (0.61) | CHEK1IKBKBJAK2MEN1EIF2AK2 | |
| SCHEMBL2455920 | 0.82 | CHEK1 (0.61) | CHEK1IKBKBJAK2MEN1EIF2AK2 | |
| SCHEMBL490749 | 0.81 | CHEK1 (0.60) | CHEK1IKBKBJAK2MEN1EIF2AK2 | |
| SCHEMBL491060 | 0.81 | CHEK1 (0.60) | CHEK1IKBKBJAK2MEN1EIF2AK2 | |
| SCHEMBL490923 | 0.81 | CHEK1 (0.55) | CHEK1IKBKBJAK2MEN1EIF2AK2 | |
| SCHEMBL490815 | 0.81 | CHEK1 (0.55) | CHEK1IKBKBJAK2MEN1EIF2AK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106091-B2 | Inhibitors of IKK-beta serine-threonine protein kinase | CHROMA THERAPEUTICS LTD. (GB) | 2012-01-31 | — | — | US | disclosed |
| EP-2086956-B1 | INHIBITORS OF IKK- BETA SERINE-THREONINE PROTEIN KINASE | CHROMA THERAPEUTICS LTD (GB) | 2011-09-14 | — | — | EP | disclosed |