Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 5/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | PRKCA | P17252 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GRK2 | P25098 | 1/20 | 0.35 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.35 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CXCR2 | P25025 | 5/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4910847 | 0.92 | MAPKAPK2 (0.42) | MAPKAPK2CYP2C9PDGFRAPRKCAMAPK1 | |
| SCHEMBL4908818 | 0.88 | MAPKAPK2 (0.42) | MAPKAPK2CYP2C9PDGFRAPRKCAMAPK1 | |
| SCHEMBL4599129 | 0.88 | MAPKAPK2 (0.45) | MAPKAPK2CYP2C9PDGFRAPRKCAMAPK1 | |
| SCHEMBL14066741 | 0.84 | HPGD (0.38) | MAPKAPK2CYP2C9PDGFRAPRKCAMAPK1 | |
| SCHEMBL14066740 | 0.82 | MAPKAPK2 (0.38) | MAPKAPK2CYP2C9PDGFRAPRKCAMAPK1 | |
| SCHEMBL4898077 | 0.81 | MAPKAPK2 (0.37) | MAPKAPK2CYP2C9PDGFRAPRKCAMAPK1 | |
| SCHEMBL4598811 | 0.81 | MAPKAPK2 (0.61) | MAPKAPK2CYP2C9PDGFRAPRKCAMAPK1 | |
| SCHEMBL4596962 | 0.81 | MAPKAPK2 (0.61) | MAPKAPK2CYP2C9PDGFRAPRKCAMAPK1 | |
| SCHEMBL4598398 | 0.80 | CXCR2 (0.41) | MAPKAPK2CYP2C9PDGFRAPRKCAMAPK1 | |
| SCHEMBL4598110 | 0.80 | MAPKAPK2 (0.49) | MAPKAPK2CYP2C9PDGFRAPRKCAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234266-A1 | Squaric Acid Derivatives II | MERCK PATENT GESELLSCHAFT (DE) | 2008-09-25 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234266-A1 | Squaric Acid Derivatives II | CHEK2, CHEK1, SGK3 | MAPKAPK2 346/4885CYP2C9 4325/4885PDGFRA 3086/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.