Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 12/20 | 0.56 |
| ▸ | BRAF | P15056 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.45 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13109969 | 0.89 | HSP90AB1 (0.70) | HSP90AB1DHODH | |
| SCHEMBL13109525 | 0.87 | HSP90AB1 (0.57) | HSP90AB1KDM4EPKM | |
| SCHEMBL13109530 | 0.86 | HSP90AB1 (0.55) | HSP90AB1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL17355415 | 0.86 | HSP90AB1 (0.56) | HSP90AB1KDM4EPKM | |
| SCHEMBL4909700 | 0.85 | TEAD2 (0.41) | HSP90AB1TEAD2DHODHKDM4EPKM | |
| SCHEMBL13109522 | 0.85 | HSP90AB1 (0.55) | HSP90AB1KDM4EPKM | |
| SCHEMBL4909743 | 0.85 | TEAD2 (0.43) | HSP90AB1TEAD2DHODHKDM4EPKM | |
| SCHEMBL3322113 | 0.84 | HSP90AB1 (0.69) | HSP90AB1DHODHKDM4ECYP2C19 | |
| SCHEMBL14281568 | 0.84 | HSP90AB1 (0.56) | HSP90AB1BRAFPDE4APDE4BPDE4C | |
| SCHEMBL13109767 | 0.84 | HSP90AB1 (0.60) | HSP90AB1KDM4EHSP90AA1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080004271-A1 | Inhibitors of TNFalpha, PDE4 and B-RAF, compositions thereof and methods of use therewith | MCKENNA JEFFREY M | 2008-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004271-A1 | Inhibitors of TNFalpha, PDE4 and B-RAF, compositions thereof and methods of use therewith | PDE4A, PDE4B, BRAF | HSP90AB1 1347/4885BRAF 3/4885PDE4A 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.