Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNB2 | O95067 | 18/20 | 1.00 |
| ▸ | CDK1 | P06493 | 18/20 | 1.00 |
| ▸ | CCNB1 | P14635 | 18/20 | 1.00 |
| ▸ | CCNB3 | Q8WWL7 | 18/20 | 1.00 |
| ▸ | GSK3B | P49841 | 16/20 | 1.00 |
| ▸ | GSK3A | P49840 | 12/20 | 1.00 |
| ▸ | CDK5 | Q00535 | 11/20 | 0.69 |
| ▸ | CDK5R1 | Q15078 | 11/20 | 0.69 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.48 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1778521 | 0.84 | CCNB2 (0.72) | CCNB2CDK1CCNB1CCNB3GSK3B | |
| SCHEMBL29913067 | 0.81 | CCNB2 (1.00) | CCNB2CDK1CCNB1CCNB3GSK3B | |
| SCHEMBL491029 | 0.81 | CCNB2 (1.00) | CCNB2CDK1CCNB1CCNB3GSK3B | |
| SCHEMBL1779137 | 0.81 | CDK1 (0.68) | CCNB2CDK1CCNB1CCNB3GSK3B | |
| SCHEMBL1780235 | 0.81 | CCNB2 (0.73) | CCNB2CDK1CCNB1CCNB3GSK3B | |
| SCHEMBL1779559 | 0.80 | CCNB2 (0.67) | CCNB2CDK1CCNB1CCNB3GSK3B | |
| SCHEMBL491112 | 0.78 | CCNB2 (1.00) | CCNB2CDK1CCNB1CCNB3GSK3B | |
| SCHEMBL1779349 | 0.78 | CCNB2 (1.00) | CCNB2CDK1CCNB1CCNB3GSK3B | |
| SCHEMBL489971 | 0.78 | CCNB2 (1.00) | CCNB2CDK1CCNB1CCNB3GSK3B | |
| SCHEMBL491100 | 0.78 | CCNB2 (1.00) | CCNB2CDK1CCNB1CCNB3GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106050-B2 | 6-[1-(4-Chlorophenyl)-1-cyclopropyl][5H]pyrrolo[2,3-b]pyrazine; cyclin-dependent kinases and glycogen synthase kinase-3 inhibitor; antiproliferative, anticarcinogenic agent; neurodegenerative disorders; controlling the cell cycle apoptosis, neuronal functions, transcription and exocytosis | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2012-01-31 | — | — | US | disclosed |