Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.74 |
| ▸ | CTSD | P07339 | 2/20 | 0.74 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4908987 | 0.93 | BACE1 (0.75) | BACE1CTSDBACE2 | |
| SCHEMBL4908564 | 0.92 | BACE1 (0.76) | BACE1CTSDBACE2 | |
| SCHEMBL4905555 | 0.91 | BACE1 (0.72) | BACE1CTSDBACE2 | |
| SCHEMBL4910917 | 0.91 | BACE1 (0.72) | BACE1CTSDBACE2 | |
| SCHEMBL3375521 | 0.90 | BACE1 (0.81) | BACE1CTSDBACE2 | |
| SCHEMBL3375528 | 0.90 | BACE1 (0.81) | BACE1CTSDBACE2 | |
| SCHEMBL3374396 | 0.89 | BACE1 (0.80) | BACE1CTSDBACE2 | |
| SCHEMBL3374391 | 0.89 | BACE1 (0.80) | BACE1CTSDBACE2 | |
| SCHEMBL4909873 | 0.89 | BACE1 (0.80) | BACE1CTSDBACE2 | |
| SCHEMBL14271302 | 0.89 | BACE1 (0.75) | BACE1CTSDBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080125467-A1 | Amino-Containing Compounds Which Inhibit Memapsin 2 Beta-Secretase Activity and Methods of Use Thereof | COMENTIS, INC. | 2008-05-29 | — | — | US | claimed |
| EP-1799660-A2 | AMINO-CONTAINING COMPOUNDS WHICH INHIBIT MEMAPSIN 2 BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006034296-A2 | AMINO-CONTAINING COMPOUNDS WHICH INHIBIT MEMAPSIN 2 BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2006-03-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080125467-A1 | Amino-Containing Compounds Which Inhibit Memapsin 2 Beta-Secretase Activity and Methods of Use Thereof | BACE2, BACE1, PSEN2 | BACE1 2/4885CTSD 245/4885BACE2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.