Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 9/20 | 0.51 |
| ▸ | PDCD1 | Q15116 | 10/20 | 0.45 |
| ▸ | CD274 | Q9NZQ7 | 10/20 | 0.45 |
| ▸ | PRKDC | P78527 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14005878 | 0.94 | CNR2 (0.49) | CNR2PDCD1CD274PRKDC | |
| Acetic Acid SCHEMBL4649623 | 0.89 | CNR2 (0.51) | CNR2PDCD1CD274PRKDC | |
| Acetic Acid SCHEMBL4649738 | 0.87 | CNR2 (0.52) | CNR2PDCD1CD274PRKDC | |
| Acetic Acid SCHEMBL4649760 | 0.86 | CNR2 (0.58) | CNR2PDCD1CD274 | |
| Acetic Acid SCHEMBL4649700 | 0.83 | CNR2 (0.59) | CNR2PDCD1CD274 | |
| Acetic Acid SCHEMBL4649759 | 0.83 | CNR2 (0.51) | CNR2PDCD1CD274PRKDC | |
| SCHEMBL14005894 | 0.82 | CNR2 (0.48) | CNR2PDCD1CD274PRKDC | |
| SCHEMBL14005884 | 0.82 | PDCD1 (0.56) | CNR2PDCD1CD274 | |
| Hydrochloric Acid SCHEMBL4649783 | 0.81 | PDCD1 (0.56) | CNR2PDCD1CD274 | |
| SCHEMBL4649605 | 0.80 | CNR2 (0.56) | CNR2PRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080280868-A1 | Pyridine Derivatives and Their Use as Cb2 Receptor Modulators | GLAXO GROUP LIMITED (GB) | 2008-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080280868-A1 | Pyridine Derivatives and Their Use as Cb2 Receptor Modulators | CNR2, CNR1, TRPV1 | CNR2 1/4885PDCD1 3839/4885CD274 3874/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.