Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 13/20 | 0.54 |
| ▸ | IKBKB | O14920 | 3/20 | 0.50 |
| ▸ | JAK2 | O60674 | 2/20 | 0.50 |
| ▸ | JAK3 | P52333 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL490613 | 1.00 | CHEK1 (0.54) | CHEK1IKBKBJAK2JAK3MEN1 | |
| SCHEMBL490818 | 1.00 | CHEK1 (0.54) | CHEK1IKBKBJAK2JAK3MEN1 | |
| SCHEMBL1147929 | 0.92 | IKBKB (0.53) | CHEK1IKBKBJAK2JAK3MEN1 | |
| SCHEMBL490719 | 0.90 | CHEK1 (0.49) | CHEK1IKBKBJAK2JAK3MEN1 | |
| SCHEMBL1148075 | 0.88 | CHEK1 (0.44) | CHEK1IKBKBJAK2JAK3MEN1 | |
| SCHEMBL490463 | 0.88 | CHEK1 (0.42) | CHEK1IKBKBJAK2JAK3MEN1 | |
| SCHEMBL1147488 | 0.88 | CHEK1 (0.49) | CHEK1IKBKBJAK2JAK3MEN1 | |
| SCHEMBL1147992 | 0.88 | CHEK1 (0.49) | CHEK1IKBKBJAK2JAK3MEN1 | |
| SCHEMBL490599 | 0.83 | CHEK1 (0.46) | CHEK1IKBKBJAK2JAK3MEN1 | |
| SCHEMBL1147753 | 0.78 | CHEK1 (0.52) | CHEK1IKBKBJAK2JAK3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106091-B2 | Inhibitors of IKK-beta serine-threonine protein kinase | CHROMA THERAPEUTICS LTD. (GB) | 2012-01-31 | — | — | US | disclosed |
| EP-2086956-B1 | INHIBITORS OF IKK- BETA SERINE-THREONINE PROTEIN KINASE | CHROMA THERAPEUTICS LTD (GB) | 2011-09-14 | — | — | EP | disclosed |