⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775141 | 0.81 | — | — | |
| SCHEMBL15776322 | 0.81 | — | — | |
| SCHEMBL1289911 | 0.74 | — | — | |
| SCHEMBL16146200 | 0.71 | HDAC3 (0.36) | — | |
| SCHEMBL491155 | 0.70 | — | — | |
| SCHEMBL5451540 | 0.69 | — | — | |
| SCHEMBL491235 | 0.69 | — | — | |
| SCHEMBL23651745 | 0.68 | — | — | |
| SCHEMBL56534 | 0.67 | — | — | |
| SCHEMBL1044254 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106194-B2 | Pyrrolopyrimidine and pyrrolotriazine derivatives | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2012-01-31 | — | — | US | disclosed |
| US-20110137031-A1 | PYRROLOPYRIMIDINE AND PYRROLOTRIAZINE DERIVATIVES | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2011-06-09 | — | — | US | disclosed |
| CN-1910185-B | Pyrrolopyrimidine and pyrrolotriazine derivatives as CRF receptor antagonists | TAISHO PHARMACEUTICAL CO LTD | 2010-05-26 | — | — | CN | disclosed |
| US-20070270588-A1 | Pyrrolopyrimidine Derivatives | TAISHO PHARMACEUTICAL CO., LTD. | 2007-11-22 | — | — | US | disclosed |
| CN-1910185-A | Pyrrolopyrimidine and pyrrolotriazine derivatives as CRF receptor antagonists | TAISHO PHARMACEUTICAL CO LTD (JP) | 2007-02-07 | — | — | CN | disclosed |
| EP-1706410-A2 | PYRROLOPYRIMIDINE AND PYRROLOTRIAZINE DERIVATIVES AS CRF RECEPTOR ANTAGONISTS | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2006-10-04 | — | — | EP | disclosed |
| WO-2005066142-A2 | PYRROLOPYRIMIDINE AND PYRROLOTRIAZINE DERIVATIVES AS CRF RECEPTOR ANTAGONISTS | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2005-07-21 | — | — | WO | disclosed |