⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20558709 | 0.97 | TSHR (0.41) | — | |
| SCHEMBL28496763 | 0.89 | TSHR (0.35) | — | |
| SCHEMBL220802 | 0.85 | — | — | |
| SCHEMBL15067862 | 0.85 | TSHR (0.37) | — | |
| SCHEMBL457285 | 0.81 | — | — | |
| SCHEMBL2348023 | 0.81 | — | — | |
| SCHEMBL18203766 | 0.81 | — | — | |
| SCHEMBL4195061 | 0.77 | TSHR (0.30) | — | |
| SCHEMBL4197669 | 0.77 | TSHR (0.30) | — | |
| SCHEMBL27919047 | 0.73 | AHR (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 251 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230120707-A1 | Compounds and Method of Treating COVID-19 | PFIZER INC. (US) | 2023-04-20 | — | — | US | claimed |
| US-10441946-B2 | Linear alpha-olefin catalysts and preparation and use thereof | APALENE TECHNOLOGY CO., LTD. (HANGZHOU) (CN) | 2019-10-15 | — | — | US | claimed |
| US-20180147571-A1 | NOVEL LINEAR ALPHA-OLEFIN CATALYSTS AND PREPARATION AND USE THEREOF | APALENE TECHNOLOGY CO., LTD. (JIAXING) (CN) | 2018-05-31 | — | — | US | claimed |
| CN-104016990-B | A kind of Imidazopyrazines analog derivative and preparation method and application | SHANDONG UNIVERSITY (CN) | 2016-11-30 | — | — | CN | claimed |
| EP-2526081-B1 | METHOD FOR PRODUCING ARYL AND HETEROARYLACETIC ACID DERIVATIVES | BAYER IP GMBH (DE) | 2015-07-01 | — | — | EP | claimed |
| CN-103360398-B | Triazolopyrimidine HIV-1 retrovirus inhibitor and its preparation method and application thereof | UNIV SHANDONG | 2015-03-25 | — | — | CN | claimed |
| US-8507688-B2 | Process for preparing aryl- and heteroarylacetic acid derivatives | BAYER CROPSCIENCE AG (DE) | 2013-08-13 | — | — | US | claimed |
| US-8309735-B2 | Heterocyclic compounds for the inhibition of integrins and use thereof | SHIRE ORPHAN THERAPIES GMBH (DE) | 2012-11-13 | — | — | US | claimed |
| US-8026248-B2 | 4-[[4-[(2,6-dichloro-phenyl)methyl]-6-[[2-(1-pyrrolidinyl)ethyl]amino]-2-pyrimidinyl]amino]benzonitrile; 4-[[4-[(2,4,6-trimethylphenyl)amino]-2-pyrimidinyl]amino]benzamide, N1-oxide combined with another retrovirus inhibitor; viricides; treatment of AIDS | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-09-27 | — | — | US | claimed |
| US-20110184180-A1 | Process for Preparing Aryl- and Heteroarylacetic Acid Derivatives | BAYER CROPSCIENCE AG (DE) | 2011-07-28 | — | — | US | claimed |
| US-20030083317-A1 | HIV inhibiting pyrimidine derivatives | ANDRIES KOENRAAD JOZEF LODEWIJ (BE) | 2003-05-01 | — | — | US | claimed |
| EP-0945443-B1 | HIV inhibiting pyrimidine derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2003-02-12 | — | — | EP | claimed |
| EP-1245567-A1 | HIV inhibiting pyrimidine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-10-02 | — | — | EP | claimed |
| US-6440986-B2 | VIRICIDES | JANSSEN PHARMACEUTICA, N.V. (BE) | 2002-08-27 | — | — | US | claimed |
| US-20010011094-A1 | HIV inhibiting pyrimidine derivatives | ANDRIES KOENRAAD JOZEF LODEWIJ (BE) | 2001-08-02 | — | — | US | claimed |
| CN-1295564-A | HIV inhibiting pyrimidine derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2001-05-16 | — | — | CN | claimed |
| WO-1999050250-A1 | HIV INHIBITING PYRIMIDINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1999-10-07 | — | — | WO | claimed |
| EP-0945443-A1 | HIV inhibiting pyrimidine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1999-09-29 | — | — | EP | claimed |
| EP-0256798-B1 | ANAESTHETIC COMPOSITION | Anaquest, Inc. (US) | 1991-09-25 | — | — | EP | claimed |
| US-4859685-A | Anesthetic composition and method of using the same | BOC, INC. (US) | 1989-08-22 | — | — | US | claimed |