Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NEK2 | P51955 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4917058 | 0.84 | PTK2 (0.47) | PTK2CYP1A2CYP3A4CYP2C19CLK4 | |
| SCHEMBL4916374 | 0.84 | PDE5A (0.50) | PTK2CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL4649832 | 0.81 | PTK2 (0.50) | NPC1RAB9APTK2CYP1A2CYP3A4 | |
| SCHEMBL4916505 | 0.81 | CDK2 (0.58) | NEK2CDK2CDK1CDK9CCNT1 | |
| SCHEMBL4920060 | 0.80 | SCN9A (0.43) | HPGDSMN1; SMN2PTK2CYP1A2CYP3A4 | |
| SCHEMBL4919889 | 0.80 | CDK2 (0.43) | PTK2NEK2CDK2CDK1BRD4 | |
| SCHEMBL4919702 | 0.79 | PDE5A (0.42) | HPGDPTK2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4914819 | 0.78 | PDE5A (0.44) | PTK2CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL4916480 | 0.78 | BRD4 (0.43) | PTK2BRD4JAK3 | |
| SCHEMBL4917738 | 0.78 | MAPT (0.46) | PTK2ALDH1A1TSHRCDK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080261973-A1 | Sulphonamidoaniline Derivatives Being Janus Kinase Inhibitors | NOVARTIS AG (CH) | 2008-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080261973-A1 | Sulphonamidoaniline Derivatives Being Janus Kinase Inhibitors | GRK4, JAK2, ALK | NPC1 2709/4885AR 136/4885HPGD 3789/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.