Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 3/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.35 |
| ▸ | STK16 | O75716 | 2/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4919330 | 0.87 | PDE5A (0.41) | PDE5APTK2LMNAMEN1KMT2A | |
| SCHEMBL4914819 | 0.78 | PDE5A (0.44) | PDE5APTK2LMNAMEN1KMT2A | |
| SCHEMBL4649788 | 0.77 | CYP19A1 (0.44) | F2LMNAMEN1MAPTKMT2A | |
| SCHEMBL4916374 | 0.76 | PDE5A (0.50) | PDE5APTK2LMNAMEN1MAPT | |
| SCHEMBL4917306 | 0.74 | PTK2 (0.48) | PDE5APTK2LMNAMEN1MAPT | |
| SCHEMBL4922248 | 0.74 | PTK2 (0.43) | PDE5ANTRK1PTK2LMNAMEN1 | |
| SCHEMBL4912787 | 0.73 | PTK2 (0.51) | PDE5ANTRK1PTK2KDM4EALDH1A1 | |
| SCHEMBL4920844 | 0.71 | CYP1A2 (0.55) | KDRPDE5APTK2LMNAMEN1 | |
| SCHEMBL4919702 | 0.71 | PDE5A (0.42) | PDE5APTK2LMNAMEN1MAPT | |
| SCHEMBL4909992 | 0.71 | PDE5A (0.43) | PDE5ANTRK1PTK2LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080261973-A1 | Sulphonamidoaniline Derivatives Being Janus Kinase Inhibitors | NOVARTIS AG (CH) | 2008-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080261973-A1 | Sulphonamidoaniline Derivatives Being Janus Kinase Inhibitors | GRK4, JAK2, ALK | RET 15/4885KDR 559/4885PDE5A 1383/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.