Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 10/20 | 0.54 |
| ▸ | KDR | P35968 | 4/20 | 0.49 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.40 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | LYN | P07948 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | BLK | P51451 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.39 |
| ▸ | IDH2 | P48735 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2335223 | 0.82 | NTRK1 (0.51) | NTRK1KDRRIPK1IDH2ALDH1A1 | |
| SCHEMBL4260344 | 0.81 | KDR (0.56) | NTRK1KDREPHA3EPHB4KIT | |
| SCHEMBL4260345 | 0.79 | KDR (0.49) | NTRK1KDRABL1LCKFYN | |
| SCHEMBL9946889 | 0.77 | NTRK1 (0.51) | NTRK1KDRABL1LCKFYN | |
| SCHEMBL2333899 | 0.76 | NTRK1 (0.51) | NTRK1KDRABL1LCKFYN | |
| SCHEMBL28141722 | 0.75 | NTRK1 (0.49) | NTRK1KDRIDH2HCRTR1ALDH1A1 | |
| SCHEMBL2336030 | 0.75 | KDR (0.68) | NTRK1KDR | |
| SCHEMBL4260680 | 0.74 | KDR (0.52) | NTRK1KDRABL1LCKFYN | |
| SCHEMBL4259330 | 0.74 | KDR (0.52) | NTRK1KDRABL1LCKFYN | |
| SCHEMBL4260334 | 0.73 | KDR (0.78) | NTRK1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004631-A1 | N-OXIDES OF HETEROCYCLIC SUBSTITUTED BISARYLUREAS FOR TREATING KINASE-MEDIATED DISEASES | Merck Patent GmbH (DE) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007115670-A1 | N-OXIDES OF HETEROCYCLIC SUBSTITUTED BISARYLUREAS FOR TREATING KINASE-MEDIATED DISEASES | MERCK PATENT GMBH (DE) | 2007-10-18 | — | — | WO | disclosed |