Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Nitrous Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitrous Acid SCHEMBL28257940 | 0.94 | — | — | |
| Nitrous Acid SCHEMBL18095956 | 0.93 | CA1 (1.00) | — | |
| Nitrous Acid SCHEMBL1057 | 0.93 | — | — | |
| Nitrous Acid SCHEMBL30577922 | 0.93 | — | — | |
| Nitrous Acid SCHEMBL10526485 | 0.93 | — | — | |
| Nitrous Acid SCHEMBL20212027 | 0.93 | — | — | |
| Nitrous Acid SCHEMBL2328305 | 0.93 | — | — | |
| Nitrous Acid SCHEMBL21951496 | 0.86 | — | — | |
| Nitrous Acid SCHEMBL22390818 | 0.86 | — | — | |
| Nitrous Acid SCHEMBL21951465 | 0.86 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117903165-A | Synthesis method of thienyl thiazole bromide | 南京欧纳壹有机光电有限公司 | 2024-04-19 | — | — | CN | claimed |
| CN-108794329-A | Synthetic method of 2, 5-dibromophenylacetic acid | 海门市新港医药科技有限公司 | 2018-11-13 | — | — | CN | claimed |
| CN-104693019-B | Method for preparing 2, 5-dibromo-benzene acetic acid | 宁波九胜创新医药科技有限公司 | 2017-02-01 | — | — | CN | claimed |
| CN-117903165-A | Synthesis method of thienyl thiazole bromide | 南京欧纳壹有机光电有限公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-104558106-B | Preparation method of medicine for treating hepatitis C | 广东东阳光药业有限公司 | 2019-12-10 | — | — | CN | disclosed |
| US-10370409-B2 | Synthesis of libraries of peptide tertiary amides | THE SCRIPPS RESEARCH INSTITUTE (US) | 2019-08-06 | — | — | US | disclosed |
| CN-108794329-A | Synthetic method of 2, 5-dibromophenylacetic acid | 海门市新港医药科技有限公司 | 2018-11-13 | — | — | CN | disclosed |
| CN-108794329-A | Synthetic method of 2, 5-dibromophenylacetic acid | 海门市新港医药科技有限公司 | 2018-11-13 | — | — | CN | disclosed |
| EP-2771478-B1 | SYNTHESIS OF LIBRARIES OF PEPTIDE TERTIARY AMIDES | SCRIPPS RESEARCH INST (US) | 2018-03-14 | — | — | EP | disclosed |
| CN-104693019-B | Method for preparing 2, 5-dibromo-benzene acetic acid | 宁波九胜创新医药科技有限公司 | 2017-02-01 | — | — | CN | disclosed |
| US-20140315831-A1 | Synthesis of Libraries of Peptide Tertiary Amides | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION INCORPORATED | 2014-10-23 | — | — | US | disclosed |
| US-20050176754-A1 | Indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof | MEMORY PHARMACEUTICALS CORPORATION | 2005-08-11 | — | — | US | disclosed |
| WO-2005063767-A2 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, AND 1,2-BENZISOTHIAZOLES, AND PREPARATION AND USES THEREOF | MEMORY PHARMACEUTICALS CORPORATION (US) | 2005-07-14 | — | — | WO | disclosed |
| CN-1575273-A | 3,4-di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor antagonists | SCHERING CORP (US) | 2005-02-02 | — | — | CN | disclosed |
| WO-2004046118-A2 | 2-4-(DI-PHENYL-AMINO)-PYRIMIDINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2004-06-03 | — | — | WO | disclosed |
| CN-1411456-A | Chemokine receptor binding heterocyclic compounds | ANORMED INC (CA) | 2003-04-16 | — | — | CN | disclosed |
| US-20010003135-A1 | Chemical process for the stereoselective synthesis of R-(-)- carnitine | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2001-06-07 | — | — | US | disclosed |
| EP-0442315-A1 | Method for separating ionic species using capillary electrophoresis | WATERS INVESTMENTS LIMITED (US) | 1991-08-21 | — | — | EP | disclosed |
| US-4820725-A | MITICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1989-04-11 | — | — | US | disclosed |
| EP-0195947-A2 | Beta-lactam antibiotics, process for their preparation and their use as and in medicaments | BAYER AG (DE) | 1986-10-01 | — | — | EP | disclosed |