Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT4 | P35916 | 7/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.55 |
| ▸ | FLT3 | P36888 | 6/20 | 0.55 |
| ▸ | AURKA | O14965 | 7/20 | 0.53 |
| ▸ | CSF1R | P07333 | 5/20 | 0.49 |
| ▸ | KIT | P10721 | 2/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4924578 | 0.99 | FLT4 (0.54) | FLT4PDGFRBFLT3AURKACSF1R | |
| SCHEMBL3427294 | 0.95 | PDGFRB (0.58) | FLT4PDGFRBFLT3AURKACSF1R | |
| SCHEMBL2052693 | 0.92 | PDGFRB (0.53) | FLT4PDGFRBFLT3AURKACSF1R | |
| SCHEMBL4642749 | 0.91 | PDGFRB (0.49) | FLT4PDGFRBFLT3AURKACSF1R | |
| SCHEMBL6027640 | 0.89 | PDGFRB (0.51) | FLT4PDGFRBFLT3AURKACSF1R | |
| SCHEMBL2052335 | 0.88 | FLT4 (0.60) | FLT4PDGFRBFLT3AURKACSF1R | |
| SCHEMBL3424548 | 0.87 | PDGFRB (0.54) | FLT4PDGFRBFLT3AURKACSF1R | |
| SCHEMBL4923004 | 0.86 | AURKA (0.51) | FLT4PDGFRBFLT3AURKACSF1R | |
| SCHEMBL4926567 | 0.86 | PDGFRB (0.46) | FLT4PDGFRBFLT3AURKACSF1R | |
| SCHEMBL2800763 | 0.86 | AURKA (0.49) | FLT4PDGFRBFLT3AURKACSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194556-A1 | Quinazolines and Their Use as Aurora Kinase Inhibitors | ASTRAZENECA AB (SE) | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194556-A1 | Quinazolines and Their Use as Aurora Kinase Inhibitors | AURKA, AURKC, AURKB | FLT4 1241/4885PDGFRB 1853/4885FLT3 224/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.