Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 11/20 | 0.81 |
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.81 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.81 |
| ▸ | HDAC4 | P56524 | 10/20 | 0.81 |
| ▸ | HDAC7 | Q8WUI4 | 10/20 | 0.81 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.81 |
| ▸ | HDAC10 | Q969S8 | 10/20 | 0.81 |
| ▸ | HDAC11 | Q96DB2 | 10/20 | 0.81 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.81 |
| ▸ | HDAC9 | Q9UKV0 | 10/20 | 0.81 |
| ▸ | HDAC5 | Q9UQL6 | 10/20 | 0.81 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | FAAH | O00519 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4925798 | 0.90 | HDAC3 (0.87) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL4920553 | 0.90 | HDAC4 (1.00) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL4927435 | 0.86 | HDAC3 (0.76) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL4920179 | 0.84 | HDAC3 (0.76) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL4925628 | 0.83 | HDAC1 (0.82) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL19293986 | 0.81 | POLB (0.71) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL4927500 | 0.80 | HDAC3 (0.76) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL4921227 | 0.79 | HDAC3 (0.74) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL4921200 | 0.79 | HDAC3 (0.78) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL4916796 | 0.78 | HDAC3 (0.66) | HDAC1HDAC6HDAC3HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080207694-A1 | Hydroxamates as Histone Deacetylase Inhibitors and Pharmaceutical Formulations Containing Them | ROSSI CRISTINA | 2008-08-28 | — | — | US | claimed |
| US-20080207694-A1 | Hydroxamates as Histone Deacetylase Inhibitors and Pharmaceutical Formulations Containing Them | ROSSI CRISTINA | 2008-08-28 | — | — | US | disclosed |
| EP-1868997-A1 | HYDROXAMATES AS HISTONE DEACETYLASE INHIBITORS AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM | Menarini International Operations Luxembourg S.A. (LU) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006097460-A1 | HYDROXAMATES AS HISTONE DEACETYLASE INHIBITORS AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM | MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A. (LU) | 2006-09-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207694-A1 | Hydroxamates as Histone Deacetylase Inhibitors and Pharmaceutical Formulations Containing Them | HDAC1, HDAC8, HDAC9 | HDAC1 1/4885HDAC6 11/4885HDAC3 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.