Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.71 |
| ▸ | BACE2 | Q9Y5Z0 | 11/20 | 0.64 |
| ▸ | CTSD | P07339 | 8/20 | 0.58 |
| ▸ | APP | P05067 | 2/20 | 0.56 |
| ▸ | REN | P00797 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4785423 | 0.91 | BACE1 (0.59) | BACE1BACE2CTSDREN | |
| SCHEMBL4125145 | 0.89 | BACE1 (0.57) | BACE1BACE2CTSDREN | |
| SCHEMBL22026027 | 0.87 | BACE1 (0.55) | BACE1BACE2CTSDREN | |
| SCHEMBL4784387 | 0.86 | BACE1 (0.58) | BACE1BACE2CTSDREN | |
| SCHEMBL8237505 | 0.86 | BACE1 (0.57) | BACE1BACE2CTSDREN | |
| SCHEMBL22026066 | 0.86 | BACE1 (0.55) | BACE1BACE2CTSDREN | |
| SCHEMBL22028603 | 0.85 | BACE1 (0.52) | BACE1BACE2CTSDREN | |
| SCHEMBL22029422 | 0.85 | BACE1 (0.52) | BACE1BACE2CTSDREN | |
| SCHEMBL4237913 | 0.85 | BACE1 (0.79) | BACE1BACE2CTSD | |
| SCHEMBL4237107 | 0.83 | BACE1 (0.73) | BACE1BACE2CTSDAPPREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076046-A1 | NOVEL 2-AMINO-5, 5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |