Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 9/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 9/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 9/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 9/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 9/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 9/20 | 0.54 |
| ▸ | F10 | P00742 | 4/20 | 0.50 |
| ▸ | TMPRSS6 | Q8IU80 | 4/20 | 0.50 |
| ▸ | ST14 | Q9Y5Y6 | 4/20 | 0.50 |
| ▸ | DPP4 | P27487 | 2/20 | 0.49 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.49 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.49 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4929008 | 1.00 | HDAC8 (0.54) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4930477 | 0.88 | HDAC3 (0.54) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4930468 | 0.88 | HDAC3 (0.54) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4920063 | 0.88 | HDAC8 (0.54) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4930397 | 0.88 | DPP4 (0.53) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4930402 | 0.88 | DPP4 (0.53) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4916706 | 0.88 | HDAC8 (0.67) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4915569 | 0.88 | HDAC8 (0.67) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4915575 | 0.88 | HDAC8 (0.67) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL5175164 | 0.85 | HDAC8 (0.51) | HDAC8HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080207694-A1 | Hydroxamates as Histone Deacetylase Inhibitors and Pharmaceutical Formulations Containing Them | ROSSI CRISTINA | 2008-08-28 | — | — | US | claimed |
| CN-101155780-A | Hydroxamates as histone deacetylase inhibitors and pharmaceutical formulations containing them | MENARINI INT OPERATIONS LU SA (LU) | 2008-04-02 | — | — | CN | claimed |
| EP-1868997-A1 | HYDROXAMATES AS HISTONE DEACETYLASE INHIBITORS AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM | Menarini International Operations Luxembourg S.A. (LU) | 2007-12-26 | — | — | EP | claimed |
| WO-2006097460-A1 | HYDROXAMATES AS HISTONE DEACETYLASE INHIBITORS AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM | MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A. (LU) | 2006-09-21 | — | — | WO | claimed |
| US-20080207694-A1 | Hydroxamates as Histone Deacetylase Inhibitors and Pharmaceutical Formulations Containing Them | ROSSI CRISTINA | 2008-08-28 | — | — | US | disclosed |
| CN-101155780-A | Hydroxamates as histone deacetylase inhibitors and pharmaceutical formulations containing them | MENARINI INT OPERATIONS LU SA (LU) | 2008-04-02 | — | — | CN | disclosed |
| EP-1868997-A1 | HYDROXAMATES AS HISTONE DEACETYLASE INHIBITORS AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM | Menarini International Operations Luxembourg S.A. (LU) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006097460-A1 | HYDROXAMATES AS HISTONE DEACETYLASE INHIBITORS AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM | MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A. (LU) | 2006-09-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207694-A1 | Hydroxamates as Histone Deacetylase Inhibitors and Pharmaceutical Formulations Containing Them | HDAC1, HDAC8, HDAC9 | HDAC8 2/4885HDAC3 8/4885HDAC4 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.