Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 7/20 | 0.69 |
| ▸ | SRC | P12931 | 6/20 | 0.69 |
| ▸ | KDR | P35968 | 6/20 | 0.69 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.69 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.69 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.69 |
| ▸ | BCR | P11274 | 3/20 | 0.69 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.69 |
| ▸ | TNNI3K | Q59H18 | 3/20 | 0.69 |
| ▸ | BRAF | P15056 | 3/20 | 0.69 |
| ▸ | CDK2 | P24941 | 2/20 | 0.69 |
| ▸ | CDK8 | P49336 | 2/20 | 0.69 |
| ▸ | AXL | P30530 | 2/20 | 0.69 |
| ▸ | FLT3 | P36888 | 2/20 | 0.69 |
| ▸ | MERTK | Q12866 | 2/20 | 0.69 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.69 |
| ▸ | STK25 | O00506 | 1/20 | 0.69 |
| ▸ | CIT | O14578 | 1/20 | 0.69 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.69 |
| ▸ | IKBKB | O14920 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4937797 | 0.91 | SRC (0.72) | ABL1SRCKDRMKNK2MKNK1 | |
| SCHEMBL3183607 | 0.91 | SRC (0.82) | ABL1SRCKDRMKNK2MKNK1 | |
| SCHEMBL13991087 | 0.90 | KDR (0.70) | ABL1SRCKDRMKNK2MKNK1 | |
| SCHEMBL4936158 | 0.90 | KDR (0.70) | ABL1SRCKDRMKNK2MKNK1 | |
| SCHEMBL4931443 | 0.89 | SRC (0.69) | ABL1SRCKDRMKNK2MKNK1 | |
| SCHEMBL4935112 | 0.89 | SRC (0.69) | ABL1SRCKDRMKNK2MKNK1 | |
| SCHEMBL3166521 | 0.89 | KDR (0.69) | ABL1SRCKDRMKNK2MKNK1 | |
| SCHEMBL4933283 | 0.89 | SRC (0.69) | ABL1SRCKDRMKNK2MKNK1 | |
| SCHEMBL13991086 | 0.88 | SRC (0.67) | ABL1SRCKDRMKNK2MKNK1 | |
| SCHEMBL4938628 | 0.84 | SRC (0.60) | ABL1SRCKDRMKNK2MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080312192-A1 | Diaryl Urea Derivatives in the Treatment of Protein Kinase Dependent Diseases | BOLD GUIDO | 2008-12-18 | — | — | US | claimed |
| US-20080312192-A1 | Diaryl Urea Derivatives in the Treatment of Protein Kinase Dependent Diseases | BOLD GUIDO | 2008-12-18 | — | — | US | disclosed |
| US-20080312192-A1 | Diaryl Urea Derivatives in the Treatment of Protein Kinase Dependent Diseases | BOLD GUIDO | 2008-12-18 | — | — | US | disclosed |
| US-20080312192-A1 | Diaryl Urea Derivatives in the Treatment of Protein Kinase Dependent Diseases | BOLD GUIDO | 2008-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312192-A1 | Diaryl Urea Derivatives in the Treatment of Protein Kinase Dependent Diseases | RET, PRKDC, PRKACA | ABL1 51/4885SRC 203/4885KDR 1309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.